Oncogene Numerical Imbalances Analysis in Laryngeal Squamous Cell Carcinoma.

Background/aim: The over-activation of oncogenes is a critical genetic event in the development and progression of solid malignancies. Gene amplification and specific mutations represent the prominent mechanisms that convert proto-oncogenes into their active, oncogenic forms. oncogene (gene locus: 8q24.

Connexin-43 Protein Expression Pattern Analysis in Myocardial Infarction Tissues.

Background/aim: Ischemic heart disease is a leading cause of death worldwide in comparison to malignant neoplasia. Myocardial infarction (MI) is the result of severe ischemia due to a low consumption of oxygen in the myocardium. The main pathophysiological reason is a progressive obstructive atherosclerotic endothelial lesion that causes reduction in coronary blood flow and increases the corresponding arterial stenosis.

Micro-Epigenetic Markers in Viral Genome: SARS-CoV-2 Infection Impact on Host Cell MicroRNA Landscape.

Introduction: MicroRNAs (miRs) are crucial micro-genetic markers that significantly manipulate gene expression in neoplastic/malignant and non-neoplastic diseases, as viral infections. Different expression patterns of miRs seem to partially influence the response rates to specific chemo-targeted therapeutic regimens and prognosis in cancer patients. Concerning their nature, miRs are short non-coding RNAs including 20-25 nucleotides hosted in intra- or intergenic regions.

Caspase 3 Expression Profiles in Meningioma Subtypes Based on Tissue Microarray Analysis.

Background/aim: Concerning primary central nervous system neoplasms, meningiomas demonstrate the most common type in adults worldwide. Deregulation of apoptotic pathways in malignancies, including meningiomas, is correlated with chemoresistance and poor prognosis. Caspases represent crucial proteins that induce cell apoptosis.