Petal-x Visualization for Lifestyle Change in Patients at Risk of Cardiovascular Diseases: An Evaluation.

Cardiovascular diseases (CVDs) are the leading global cause of death and addressing unhealthy lifestyles is essential for reducing CVD risk. Visual explanations, such as the Petal-X dashboard, can support personalized care by improving patients' understanding of health risks and motivating lifestyle changes. This study evaluated whether the Petal-X dashboard, utilizing the SCORE2 model for 10-year CVD risk calculation, promotes lifestyle changes and subsequently reduces CVD risk.

Assessment and management of portal hypertension in patients with MASLD: advances and caveats.

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly gaining relevance both as a public health issue and a clinical challenge. The development of portal hypertension in MASLD challenges traditional paradigm that it arises only in the context of cirrhosis.

Areas Covered: This review explores the understanding of portal hypertension in MASLD, addressing recent advances in pathophysiology, diagnosis, and potential therapeutic approaches.

Metabolomic Changes Associated With the Change in HVPG After DAAs Therapy in HCV Cirrhotic Patients.

Background And Aims: In response to direct-acting antivirals (DAAs) therapy, patients who experience a decrease in hepatic venous pressure gradient (HVPG) considerably reduce liver complications and have increased survival. This study aimed to assess the metabolomic changes associated with the changes in HVPG from the start of DAA therapy until 48 weeks after effective DAA therapy in patients with advanced HCV-related cirrhosis.

Methods: We carried out a multicenter longitudinal study in 31 patients with advanced hepatitis C virus (HCV)-related cirrhosis.

Altered blood microbiome in patients with HCV-related Child-Pugh class B cirrhosis.

Background: Altered bacterial translocation is associated with changes in hepatic function and the progression from compensated to decompensated cirrhosis. Child-Turcotte-Pugh (CTP) score is an essential indicator of liver severity. Thus, we aimed to study differences in the blood microbiome together with metabolome profile between HCV-infected patients with CTP class B (CTP-B, significant functional compromise) and patients with CTP class A (CTP-A, well-compensated cirrhosis).

The impact of high-IgE levels on metabolome and microbiome in experimental allergic enteritis.

Background: The pathological mechanism of the gastrointestinal forms of food allergies is less understood in comparison to other clinical phenotypes, such as asthma and anaphylaxis Importantly, high-IgE levels are a poor prognostic factor in gastrointestinal allergies.

Methods: This study investigated how high-IgE levels influence the development of intestinal inflammation and the metabolome in allergic enteritis (AE), using IgE knock-in (IgEki) mice expressing high levels of IgE. In addition, correlation of the altered metabolome with gut microbiome was analysed.