Healthy participant engagement in early clinical trials: results from the European EUFEMED survey.

Introduction: While numerous healthy volunteers contribute to clinical trials on a yearly basis, the aspect of including these participants in the drug development process, like the patient-centric approaches, are not well known. To gain broader insights in the aspect of healthy participant engagement, preferences, and motivation, we performed a European wide survey. Additionally, a literature search on the topic of healthy participant engagement was performed.

DNA methylation testing for vulvar cancer risk stratification in patients with high-grade vulvar intraepithelial neoplasia: a population-based cohort study.

Background: High-grade vulvar intraepithelial neoplasia (VIN) is the precursor of vulvar cancer and is divided into human papillomavirus (HPV)-associated high-grade squamous intraepithelial lesion (HSIL) and HPV-independent VIN, often clinically referred to as differentiated VIN (dVIN) and associated with vulvar dermatoses, usually lichen sclerosus. Surgical treatment of high-grade VIN often leads to genital deformity, reduced quality of life and reduced sexual function, which has a major impact on quality of life. To optimize clinical management, accurate biomarkers providing information on the cancer risk of high-grade VIN are needed.

Longitudinal evaluation of prognostic factors influencing the outcomes of functional appliance therapy in juvenile idiopathic arthritis patients with temporomandibular joint involvement.

Introduction: Temporomandibular joint (TMJ) involvement is a common yet under-recognized manifestation of Juvenile Idiopathic Arthritis (JIA) which can impair craniofacial growth and oral function. While early functional orthopaedic intervention holds promise, evidence from long-term studies evaluating outcomes and predictors of treatment response remains sparse.

Materials And Methods: This prospective longitudinal study included 84 children (mean age: 12.

Normothermic human kidney preservation drives iron accumulation and ferroptosis.

Ex vivo normothermic machine perfusion has been proposed to protect deceased donor kidneys. However, its benefits remain ambiguous. We postulate that the use of red blood cells (RBCs) and associated secondary hemolysis may in fact cause renal injury, offsetting potential advantages.

Lack of Altitude Medicine Knowledge Among Mountaineers in the Italian Alps.

Berendsen, Remco R., Dirk C A.A.