Addressing fidelity within complex health behaviour change interventions: a scoping review of fidelity frameworks and models.

Fidelity is an important but under-addressed aspect of health behaviour change intervention research. Consensus is lacking regarding terminology, definitions, and conceptualisations. Fidelity frameworks and models can help people address fidelity in a structured way and ensure clarity and consistency of terminology, but they are underutilised to date.

Exploring a coating design spacing using experimental and simulated coating techniques.

This study aimed to enhance an understanding of a laboratory-scale tablet coating process using CFD-DEM simulations to model the momentum, heat and mass transfer between the tablets and the fluid phase. Eight process points were selected from an experimental design space study and simulated in silico. The simulations were analyzed regarding the tablet movement, the coating mass distribution, the tablet and air temperatures and the solvent evaporation.

Development of a Human Evaluation Framework and Correlation with Automated Metrics for Natural Language Generation of Medical Diagnoses.

In the evolving landscape of clinical Natural Language Generation (NLG), assessing abstractive text quality remains challenging, as existing methods often overlook generative task complexities. This work aimed to examine the current state of automated evaluation metrics in NLG in healthcare. To have a robust and well-validated baseline with which to examine the alignment of these metrics, we created a comprehensive human evaluation framework.

Oral peptide drug delivery: design of SEDDS providing a protective effect against intestinal membrane-bound enzymes.

This study presents an emerging approach for oral peptide drug delivery by designing self-emulsifying drug delivery systems (SEDDS) capable of protecting peptide drugs from intestinal brush border membrane-bound (BBM) enzymes. Tuftsin was incorporated as a model peptide into three optimized SEDDS formulations through hydrophobic ion pairing with the anionic surfactants docusate (AOT), N-octadecyl sulfate (OS), and lauryl sulfate (LS). SEDDS- 1 consisted of octyldodecanol, polyoxyethylene (10) oleyl ether, polyoxyethylene (20) oleyl ether and citronellol.

Design of lipid-based formulations for oral delivery of a BASP1 peptide targeting MYC-dependent gastrointestinal cancer cells.

Hypothesis: Oral delivery of the proliferation-inhibiting brain acid-soluble protein 1 effector domain peptide (Myr-NT) towards MYC-dependent gastrointestinal tumors can be achieved by forming hydrophobic ion pairs (HIPs) and incorporating them into lipid-based formulations.

Experiments: Hydrophobic ion pairing of fluorescently-labelled Myr-NT (Myr-NT-TAMRA) was performed, increase in lipophilicity was assessed, and the most promising HIP was subsequently incorporated into a nanoemulsion. Stability of the peptide towards degradation by trypsin was evaluated.