pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors.

Transient receptor potential classical or cation channels (TRPCs) are integral to tumor biology, particularly in maintaining Ca homeostasis within cancer cells. TRPC5, a pH-sensitive member of this family, may act as a signaling molecule in the altered microenvironment of solid tumors, which are characterized by an inverted pH-gradient-with decreased extracellular and increased intracellular pH-that promotes tumor progression. This study addresses a gap in the field, as there is currently limited research on TRPC5, particularly regarding its potential role as a tumor marker.

Explainable, federated deep learning model predicts disease progression risk of cutaneous squamous cell carcinoma.

Predicting cancer patient disease progression is a key step towards personalized medicine and secondary prevention. Risk stratification systems based on clinico-pathological criteria aim to identify high-risk patients, but accurate predictions remain challenging. Deep learning models present new opportunities for patient risk prediction, yet their interpretability has been largely unexplored.

Determinants of Quality of Life in Patients with Atopic Dermatitis and Psoriasis: A Multivariate Approach.

Health-related quality of life (HRQoL) is reduced in atopic dermatitis and psoriasis. Several factors impact HRQoL including sociodemographic and skin disease-related characteristics, health behaviours, cardiometabolic comorbidities, and psychological conditions. However, their differential and unique effects on HRQoL are not well studied.

Environmental Impact of Dermatology and Action Towards It: A Narrative Review.

There is a dual interplay between the environment and healthcare, which is associated with around 6% of global greenhouse gas (GHG) emissions, high water consumption, and large volumes of waste. Dermatology encompasses peculiarities such as the extensive use of topicals and cosmeceuticals, specific procedural treatments, and a wide range of activities spanning from dermatopathology to the use of biologicals. Some of these aspects might bear a significant environmental footprint, which has been characterized insufficiently until this point.