Caring for carers of people with advanced cancer at hospital discharge (CARENET): A single-arm open label feasibility trial.

Objectives: Carers are critical to support discharge home from hospital at end of life yet remain under-represented in health service initiatives to assist this transition. A carer-focused intervention embedded into practice may facilitate hospital discharge. This open-labeled, single-arm phase 2 study aimed to determine the feasibility of (1) delivering a multi-staged intervention (CARENET) to carers of advanced cancer patients in a hospital setting and (2) the study design to inform a phase 3 trial.

A Meta-Analysis of Sex-Based Differences in Health Service Use for Persons Living With Dementia Between 2018 and 2020 in Four Canadian Provinces.

Background: Ensuring equitable healthcare services for persons with dementia is of utmost importance. Recent evidence points to sex-based differences in healthcare use in this population. However, available evidence is based on data from limited geographic regions and predates the COVID-19 pandemic, which is said to have further magnified disparities.

A scoping review of innovations that promote interprofessional collaboration (IPC) in primary care for older adults living with age-related chronic disease in rural areas.

Background And Objectives: An aging population and associated multi-morbid chronic diseases (CDs) require comprehensive health care across multiple disciplines. Literature suggests interprofessional collaboration (IPC) in primary care is effective for CD models of care. However, IPC requires innovative implementation, particularly in rural and remote areas where access to health care services and providers is often limited.

The association between previous SARS-CoV-2 infection and incidence of stroke.

Objectives: To define the association between prior SARS-CoV-2 infection and incidence of stroke.

Methods: We conducted a case-control study combining the Qatar stroke database and the Qatar National COVID-19 databases. Cases with stroke diagnosis were matched 1:1 on demographics, comorbidities, and vaccination status to controls who tested negative for SARS-CoV-2 during the same week.

Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells.

Chimeric antigen receptor (CAR) T cell therapy targeting CD19 elicits remarkable clinical efficacy in B cell malignancies, but many patients relapse owing to failed expansion and/or progressive loss of CAR-T cells. We recently reported a strategy to potently restimulate CAR-T cells in vivo, enhancing their functionality by administration of a vaccine-like stimulus comprised of surrogate peptide ligands for a CAR linked to a lymph node-targeting amphiphilic PEG-lipid (amph-vax). Here we demonstrate a general strategy to discover and optimize peptide mimotopes enabling amph-vax generation for any CAR.