Key factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks.

Background: Major depressive disorder (MDD) is associated with neuro-immune - metabolic - oxidative (NIMETOX) pathways.

Aims: To examine the connections among NIMETOX pathways in outpatient MDD (OMDD) with and without metabolic syndrome (MetS); and to determine the prevalence of NIMETOX aberrations in a cohort of OMDD patients.

Methods: We included 67 healthy controls and 66 OMDD patients and we assessed various NIMETOX pathways.

Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function.

Myelination is essential for normal brain function, yet the mechanisms governing neuron-oligodendrocyte interactions that ensure proper myelination levels remain poorly understood. Here, we identify transcription factor EB (TFEB) as a molecular link that connects extrinsic neuronal cues to intrinsic oligodendrocyte transcriptional programs, regulating central nervous system myelination. Using a TFEB epitope-tagged knock-in mouse model, we find that neurons sequester most of the TFEB protein in the cytoplasm of myelinating oligodendrocytes.

Factors associated with the willingness of young people in higher education to adhere to syphilis screening.

Objectives: to investigate factors associated with willingness to know one's syphilis serological status among higher education students.

Methods: a cross-sectional and analytical study conducted with higher education students in Portugal. Data collection was carried out through an online questionnaire.

Unlocking the anti-aging potential: In silico analysis of astaxanthin, curcumin, quercetin, and resveratrol in modulating skin aging pathways.

Multiple studies have linked aging to a result of the inflammatory response. Thus, there is a recognized need for cosmeceuticals that modulate inflammation pathways to prevent and treat aging. In this sense, four bioactive compounds were selected for their documented anti-inflammatory/antioxidant properties.

Efficacy of the adapted Cycles approach in telepractice speech-language pathology with a parental focus for children with speech sound disorders.

Purpose: To evaluate the effectiveness of the adapted Cycles approach to telepractice and family engagement in the treatment of children with speech sound disorder (SSD).

Methods: Ten children aged 5:0 to 7:8 years with a diagnosis of SSD participated. Two multiple baseline assessments and two post-treatment assessments were conducted.