"A Hybrid Surgical Technique for Bilateral Cleft Lip Reconstruction".

The treatment of bilateral cleft lip (BCL) is inherently complex, attributed to the discontinuity of the orbicularis oris muscle, significant nasal deformities, and the distinctive anatomical characteristics of the prolabium1. Several operative techniques exist, including the well-known Millard and Manchester methods. The Manchester technique preserves the vermilion of the prolabium, joining them with the lateral lip components2.

Localized high-risk prostate cancer harbors an androgen receptor activity-low subpopulation susceptible to HER2 inhibition.

Background: Localized high-risk prostate cancer (PCa) often recurs despite neoadjuvant androgen deprivation therapy (ADT). We sought to identify baseline molecular programs that predict pathologic response and reveal targetable vulnerabilities.

Methods: We profiled 147 biopsy foci from 48 MRI-visible lesions in 37 patients before 6 months of ADT plus enzalutamide and radical prostatectomy.

Factors affecting technical success of endoscopic retrograde cholangiopancreatographic outcomes in patients with surgically altered foregut anatomy: a retrospective study.

Introduction: Patients with surgically altered gastrointestinal anatomy undergoing endoscopic retrograde cholangiopancreatography (ERCP) pose challenges due to anatomical distortions. Various patient and endoscopic factors, such as sex and positioning, may impact procedural success. It is unclear how these factors may impact the technical success of ERCP among patients with altered anatomy.

Serologic Evidence of Human Exposure to Bat-Borne Zoonotic Paramyxoviruses, Cambodia.

Fruit bats in the genus are the natural reservoirs for zoonotic paramyxoviruses, notably henipaviruses and pararubulaviruses, which are found across Southeast Asia and Oceania. The genetic and antigenic diversity of viruses in both genera, and region specificity, are ill-defined, limiting health security measures aimed at minimizing spillover. For example, Nipah virus has been isolated from bats in the Battambang province of western Cambodia, and surveys suggest bat foraging behaviors occur in close proximity to human settlements.

Machine-learning prediction of postoperative complications after high tibial osteotomy for canine cranial cruciate ligament disease.

Objective: The aim of this study was to develop and internally validate a machine-learning algorithm, PROSPECT (Predicting Risk Of Surgical complications aftEr CCWO and TPLO), using clinical variables to predict postoperative complications in dogs undergoing high tibial osteotomy for cranial cruciate ligament disease (CrCLD).

Study Design: Retrospective multivariable prediction model development.

Sample Population: Stifles (n = 670) and dogs (n = 555).