Copper-Catalyzed Coupling of -Acyl-'-Substituted Hydrazines with (Hetero)aryl Chlorides/Bromides.

The coupling of -acyl-'-substituted hydrazines with (hetero)aryl bromides and chlorides is efficiently catalyzed by CuI/4-hydroxy picolinamide and Cu(OAc)/6-hydroxy picolinohydrazide, respectively. Under these conditions, a broad range of (hetero)aryl halides and -acyl-'-substituted hydrazines react smoothly at 80-120 °C, affording the corresponding products in good to excellent yields in most cases.

Flexible, multifunctional sensor based on core-sheath sensing medium for humidity sensing and heat-resistant pressure.

The practical implementation of wearable sensing devices for human health monitoring requires significant advancements in lightweight design and multifunctional integration. Fiber-shaped sensors have attracted considerable research attention due to their ability to maintain exceptional sensitivity and measurement accuracy under various mechanical deformations, including bending, stretching, and torsion. Nevertheless, the functional integration remains constrained, particularly as evidenced by sensitivity degradation and device failure under extreme high-temperature conditions, which severely hinders their practical applicability for real-time health monitoring applications in complex environmental scenarios.

Recent Progress of 3D Printing Bioceramic Scaffolds for Bone Regeneration.

The reconstruction of critical-sized bone defects remains a challenging clinical problem. At present, the implantation of autogenous and allogeneic grafts is the main clinical treatment strategy but faces some drawbacks, such as inadequate source, donor site-related complications, and immune rejection, driving researchers to develop artificial bone substitutes based on distinct materials and fabrication technologies. Among the bone substitutes, bioceramic-based substitutes exhibit a remarkable biocompatibility, which can also be designed to degrade concomitantly with the formation of new bone.

Symmetry Breaking Assisted Fast Reverse Intersystem Crossing for Efficient TADF Materials.

Reverse intersystem crossing (RISC) process is critical for thermally activated delayed fluorescence (TADF) materials to realize spin-flip of triplet excitons in organic light-emitting diodes (OLEDs), but the RISC processes of most TADF materials are not fast enough, undermining electroluminescence (EL) efficiency stability and operational lifetime. Herein, a symmetry breaking strategy to accelerate RISC processes is proposed. By designing asymmetric electron-withdrawing backbone consisting of benzonitrile and xanthone/thioxanthone groups, two new asymmetric TADF molecules, 4tCzCN-pXT and 4tCzCN-pTXT, with multiple 3,6-di-tert-butylcarbazole donors are successfully developed.

Inter-ictal spike rates are not modulated by anti-seizure medication taper in the epilepsy monitoring unit: a tale of two confounders.

New implantable and wearable devices hold great promise to help patients manage their seizure disorders. One proposed application is measuring the rate of interictal epileptiform discharges as a biomarker of medication levels and seizure risk. This study aims to determine whether interictal epileptiform spike rates (spikes) are independently associated with anti-seizure medication (ASM) levels and evaluate whether spike rates are a reliable biomarker for ASM levels.