Artificial Intelligence and Network Medicine: Path to Precision Medicine.

Over the past two decades, network medicine (NM) has evolved to help define disease mechanisms, identify drug targets, and guide increasingly precise therapies. In recent years, the integration of NM with artificial intelligence (AI), particularly deep learning techniques, has evolved with increasing applications. AI techniques help elucidate complex disease mechanisms and define precise therapies.

Factors associated with new onset of depression and anxiety symptoms differ by sex in the COPDGene study.

Objective: Examine clinical and demographic variables associated with new onset depression and anxiety symptoms and assess moderation by sex in COPDGene, a cohort study of current and former smokers at risk for or with chronic obstructive pulmonary disease (COPD).

Methods: In the COPDGene study, 2653 adults had the hospital anxiety (HADS-A) and depression (HADS-D) scales available at phase 2 and 3, as well as clinical and demographic variables available at 2 and non-elevated HADS at phase 2. We defined new onset depression symptoms as HADS-D elevated at phase 3 (HADS-D ≥ 8) versus no new onset as HADS-D not elevated at either phase (HADS-D < 8).

Navigating COPD and Bronchiectasis: A COPD Foundation 360Social Survey of Health Care Experiences and Perceptions.

Rationale: Chronic lung diseases, including COPD and bronchiectasis (BE), may differ by sex in symptom onset, diagnostic delays, and disease burden. This study examined healthcare experiences and symptom burden among individuals with self-reported COPD, BE, or non-tuberculous mycobacteria (NTM).

Methods: This cross-sectional study analyzed data from an online survey of U.

Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging.

Mosaic loss of Y chromosome (mLOY) in blood cells is an age-related somatic mutation, but its relationship with pulmonary health remains undercharacterized. Leveraging mLOY assessment in over 12,000 men, including 5,097 from the COPDGene Study and 7,235 from six additional cohorts in Trans-Omics for Precision Medicine program, we investigated its association with respiratory outcomes and epigenetic aging. Cross-sectionally, mLOY was associated with airflow obstruction with prevalence increasing with age, particularly in men with a former smoking history.