Chromatographic determination of antidepressants in plasma and saliva: Towards non-invasive therapeutic monitoring.

Drug monitoring of antidepressants in plasma and oral fluid represents a valuable tool in clinical practice, enabling the optimisation of treatment efficacy and the reduction of adverse effects. Given the significant interindividual variability in antidepressant response-driven by factors such as metabolism, drug-drug interactions, and adherence to therapy-drug monitoring facilitates dose adjustment based on measured drug concentrations, ensuring levels remain within the therapeutic window. This study aimed at developing and validating a robust, rapid, and sensitive method for the simultaneous quantification of 21 selected antidepressants and their metabolites in only 100 μL of plasma and oral fluid.

Impacts of the COVID-19 pandemic on excess deaths: descriptive study, Pernambuco, 2020-2022.

Objective: To estimate the excess deaths during the COVID-19 pandemic in Pernambuco between 2020 and 2022.

Methods: This descriptive study used data from the Mortality Information System (SIM). The excess deaths, expressed as the observed-to-expected deaths ratio, and the P-score, expressed as the proportional excess deaths, were evaluated.

The paradoxical impact of drought on West Nile virus risk: insights from long-term ecological data.

Mosquito-borne diseases are deeply embedded within ecological communities, with environmental changes-particularly climate change-shaping their dynamics. Increasingly intense droughts across the globe have profound implications for the transmission of these diseases, as drought conditions can alter mosquito breeding habitats, host-seeking behaviours and mosquito-host contact rates. To quantify the effect of drought on disease transmission, we use West Nile virus as a model system and leverage a robust mosquito and virus dataset consisting of over 500 000 trap nights collected from 2010 to 2023, spanning a historic drought period followed by atmospheric rivers.

Mortality After Cerebral Venous Thrombosis.

Objectives: Cerebral venous thrombosis (CVT) has historically had a poor prognosis, but advances in diagnosis and treatment may have improved outcomes. This study evaluated mortality rates, causes of death, and predictors of early and late mortality in CVT using international data.

Methods: In this multicenter cohort study, we analyzed data from adults with CVT enrolled between 1995 and 2021.