Publications by authors named "D J Livy"
Background: Recent findings have demonstrated that hippocampal subfields can be selectively affected in different disease states, which has led to efforts to segment the human hippocampus with in vivo magnetic resonance imaging (MRI). However, no studies have examined the histological accuracy of subfield segmentation protocols. The presence of MRI-visible anatomical landmarks with known correspondence to histology represents a fundamental prerequisite for in vivo hippocampal subfield segmentation.
View Article and Find Full Text PDFObjective: This study sought to evaluate the efficacy of a multisensory teaching approach in imparting the necessary knowledge, technical skills, and confidence to perform a cricothyrotomy to a cohort of fourth-year medical students.
Methods: One hundred twenty students were recruited into the study. Subjects commenced by viewing an upper airway obstruction vodcast.
Article Synopsis
- While DTI is commonly used to study white matter in the brain, this research is one of the first to link DTI findings with actual brain histology in humans, specifically in TLE patients.
- TLE patients with mesial temporal sclerosis showed abnormal DTI metrics in the fimbria-fornix, indicating differences in their brain's structural integrity, which were further supported by tissue samples analyzed through electron microscopy.
- The study confirmed that DTI can reliably reflect underlying white matter abnormalities, reinforcing its value as a noninvasive diagnostic tool for brain disorders.
Children exposed prenatally to alcohol can display a variety of neural deficits, including an altered development of the corpus callosum (CC), the largest interhemispheric axon pathway in the brain. Furthermore, these children show functional abnormalities that are related to brain regions with significant numbers of CC connections. Little is known about how alcohol imparts influence on CC development, but one possible mechanism is by affecting the corpus callosum projection neurons (CCpn) directly.
View Article and Find Full Text PDFLong-term alcohol exposure prior to conception results in lower fetal body weights.
Birth Defects Res B Dev Reprod Toxicol
June 2004
Background: It is well known that alcohol consumption during pregnancy can result in lower birth weight babies but many women stop consuming alcohol prior to conception as a part of pregnancy planning. The purpose of this study was to determine whether alcohol consumption prior to conception may also have an effect on fetal development.
Methods: Male and female C57BL/6J mice at 4, 6, or 8 weeks of age received either a single administration of alcohol (3.