Comparative Immunomodulatory Efficacy of Secukinumab and Honokiol in Experimental Asthma and Acute Lung Injury.

The study evaluates the immunomodulatory potential of secukinumab (SECU) and honokiol (HONK) in a murine model of allergic asthma complicated by acute lung injury (ALI), with an emphasis on modulating key inflammatory pathways. The rationale is driven by the necessity to attenuate Th17-mediated cytokine cascades, wherein IL-17 plays a critical role, as well as to explore the adjunctive anti-inflammatory effects of HONK on Th1 cytokine production, including IL-6, TNF-α, and Th2 cytokines. Mice were sensitized and challenged with ovalbumin (OVA) and lipopolysaccharide (LPS) was administrated to exacerbate pulmonary pathology, followed by administration of SECU, HONK (98% purity, CHO), or their combination.

Biocultural tourist experience in Romania's High Nature Value rural landscape: Application of an extended Theory of Planned Behavior.

The present study looks at the interface of environment and culture, where High Nature Value (HNV) rural landscapes serve as a scene for a new type of tourism that creates a "biocultural tourist experience". This study aimed to develop and test a new conceptual framework that explains the tourists' behavioral intention formation by using an extended Theory of Planned Behavior. We used PLS-SEM on the data collected from a large-scale representative sample of 1007 Romanian people to predict their Intention to have a biocultural tourist experience in a HNV rural landscape.

Real-World Case Series of Ravulizumab Use in Patients with Myasthenia Gravis in Romania.

Ravulizumab, a long-acting C5 complement inhibitor, was approved in the US and Europe in 2022 as an add-on therapy for the standard treatment of AChR-positive generalized MG (gMG). We share our real-world experience with adult patients receiving this therapy in Romania. Six AChR-positive gMG patients received ravulizumab through an Early Access Program (January 2023-October 2024).

The Effects of Visual Behavior and Ego-Movement on Foveated Rendering Performance in Virtual Reality.

Despite the recent developments in VR, maintaining photorealism is difficult due to the increased bandwidth capabilities and computational resources required. To make VR more affordable, techniques such as Foveated Rendering (FR) offer promising ways to optimise rendering without compromising the user experience. Near-eye displays with 6DOF tracking enable users to freely move through the environment.

Mapping environmental perceptions in Romania: A mixed-methods research.

The present study investigates environmental perceptions in Romania, emphasizing their role in shaping individual and collective responses to ecological challenges. By exploring how people understand and interact with their natural environment, the research aims to explore values, needs, behaviors, and motivations that drive pro-environmental actions. We used a mixed-methodology approach, combining qualitative and quantitative analyses to capture a comprehensive view of these perceptions.