Ceftobiprole versus ceftriaxone ± linezolid in Community-Acquired Bacterial Pneumonia (CABP): Re-analysis of a randomized, phase 3 study using 2020 FDA guidance.

Background: Ceftobiprole is an advanced-generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus, resistant pneumococci, and Enterobacterales. In a Phase 3 study in community-acquired bacterial pneumonia (CABP) performed prior to the current US Food and Drug Administration (FDA) guidance, clinical cure at the test-of-cure visit (TOC) was the primary endpoint. We present a re-analysis using early clinical success as the primary endpoint per the 2020 FDA CABP Guidance.

A closer look into maternal psychological distress and the associated factors: the case of autism and chronic conditions.

Introduction: Mothers caring for children with autism or chronic illnesses may experience heightened psychological distress due to the ongoing demands associated with caregiving. This study aimed to examine levels of psychological distress among Romanian mothers of children with autism, chronic illness, or typical development, and to explore the role of health-related quality of life and emotion regulation strategies.

Methods: A total of 211 Romanian mothers aged 20 to 67 years (M = 38, SD = 8.

Thirty Years of Emergency Medicine in Romania-A Bridge Between the Behavior of Emergency Department Professionals and the Health System Management Strategy: A Survey Study.

Over the past three decades, emergency medicine in Romania has evolved from a developing specialty into a cornerstone of the national healthcare system. As we reflect on these 30 years, it becomes evident that the lessons learned and the systems developed form a vital foundation for the future. This study aims to explore how the accumulated experience can guide us toward building a more resilient emergency medical system, one that prioritizes quality, ensures patient and provider safety, and embraces modern principles of healthcare management.

The use of biomarkers testing in Emergency Department.

Introduction: In the fast-paced environment of Emergency Departments (EDs), biomarkers are essential for the rapid diagnosis and management of critical conditions.

Aim Of The Study: This study evaluates the current clinical practice on key biomarkers in Romanian EDs, addressing the needs of emergency medicine physicians, and the challenges associated with biomarker testing.

Material And Methods: An online survey was sent to physicians working in ED to explore their perceptions, needs, and barriers regarding biomarkers, including Point-of-care (POC).

Internet of Things-Cloud Control of a Robotic Cell Based on Inverse Kinematics, Hardware-in-the-Loop, Digital Twin, and Industry 4.0/5.0.

The main task of the research involves creating a Digital Twin (DT) application serving as a framework for Virtual Commissioning (VC) with Supervisory Control and Data Acquisition (SCADA) and Cloud storage solutions. An Internet of Things (IoT) integrated automation system with Virtual Private Network (VPN) remote control for assembly and disassembly robotic cell (A/DRC) equipped with a six-Degree of Freedom (6-DOF) ABB 120 industrial robotic manipulator (IRM) is presented in this paper. A three-dimensional (3D) virtual model is developed using Siemens NX Mechatronics Concept Designer (MCD), while the Programmable Logic Controller (PLC) is programmed in the Siemens Totally Integrated Automation (TIA) Portal.