Microtubule acetylation by αTAT1 is essential for touch sensation in zebrafish but dispensable for embryonic development.

Acetylation of α-tubulin at lysine 40 (α-tub) is a conserved post-translational modification that occurs on the microtubule lumenal surface, but its developmental functions remain poorly defined. In zebrafish, morpholino knockdown of α-tubulin acetyltransferase 1 (αTAT1), the enzyme responsible for depositing α-tub marks, has been reported to cause severe developmental defects, whereas genetic loss-of-function studies in mice found no overt role in development. Here, we generated αTAT1 loss-of-function alleles in zebrafish and found that, in contrast to morphants, mutants are viable, fertile, and develop normally.

Measurement-based Care Training Curriculum in Psychiatry Residency Programs: Four-year Implementation Experience and Future Directions.

Objective: In 2019, the authors began implementing a measurement-based care (MBC) curriculum into two residency programs at West Virginia University (WVU) and Delaware Psychiatric Center (DPC). The authors present findings from the four-year implementation period and describe a web-based MBC course that aims to train attendings and residents across the United States (US) and abroad.

Methods: The web-based MBC course includes four readings (the MBC instruction manual, the Standard for Clinicians' Interview in Psychiatry [SCIP] glossary, clinician-administered [CA] scales, and self-administered [SA] scales), four didactic presentations (MBC basics, psychopathology assessment, epidemiological concepts, and psychiatric measures), and four video interviews.

Developing critical thinking and decision-making skills for cancer information: the Informed Health Choice-Cancer online learning resource.

Purpose: People impacted by cancer face increasing challenges in navigating a landscape of abundant health information and misinformation. This study outlines the development and pilot testing of the Informed Health Choices-Cancer (IHC-C) learning resource, designed to provide users the skills and knowledge necessary to think critically about the reliability of health claims and make well-informed choices. This study outlines the development and pilot testing of this learning resource.

Enabling Ethanol Dehydrogenation Catalysis by Postsynthetic Anion Exchange of Triazolate-Based Metal-Organic Frameworks.

Materials containing soft, polarizable elements are expanding the boundaries of catalytic properties, offering unique electronic communication and stability characteristics compared with their harder counterparts due to the enhanced covalent nature of metal-ligand interactions. However, integrating soft components like sulfur into metal-organic frameworks (MOFs) for catalytic applications remains a largely underexplored challenge. Here, we report the synthesis of a family of triazole-based MOFs and expand upon established postsynthetic anion exchange methods to incorporate sterically encumbered polarizable elements, such as alkyl thiolates.

Introducing metal-sulfur active sites in metal-organic frameworks via post-synthetic modification for hydrogenation catalysis.

Metal-sulfur active sites play a central role in catalytic processes such as hydrogenation and dehydrogenation, yet the majority of active sites in these compounds reside on the surfaces and edges of catalyst particles, limiting overall efficiency. Here we present a strategy to embed metal-sulfur active sites into metal-organic frameworks (MOFs) by converting bridging or terminal chloride ligands into hydroxide and subsequently into sulfide groups through post-synthetic modification. We apply this method to two representative MOF families: one featuring one-dimensional metal-chloride chains and another containing discrete multinuclear metal clusters.