Lipid Composition Alters Ferroptosis Sensitivity.

Ferroptosis is a regulated non-apoptotic cell death process characterized by iron-dependent lipid peroxidation. Peroxidation of polyunsaturated fatty acid-containing phospholipids (PUFA-PLs) is necessary for the execution of ferroptosis. Glutathione peroxidase 4 (GPX4) suppresses ferroptosis by reducing lipid hydroperoxides to lipid alcohols.

A Rapid and Modular Nanobody Assay for Plug-and-Play Antigen Detection.

Rapid and portable antigen detection is essential for managing infectious diseases and responding to toxic exposures, yet current methods face significant limitations. Highly sensitive platforms like the Enzyme-Linked Immunosorbent Assay (ELISA) are time- and cost-prohibitive for point-of-need detection, while portable options like lateral flow assays (LFAs) require systemic overhauls for new targets. Furthermore, the complex infrastructure, high production costs, and extended timelines for assay development constrain the manufacturing of traditional diagnostic platforms in low-resource settings.

Prolonged Tele-Critical Care Utilization Is Associated With Improved ICU Outcomes: Evidence From Veterans Affairs Hospitals.

Objectives: To determine the impact of critical care telemedicine (tele-critical care [TCC]) implementation duration on clinical outcomes: ICU mortality, ICU length of stay (LOS), and mechanical ventilation utilization.

Design: Retrospective cohort study.

Setting: Thirty-five U.

Thinking beyond the tablet: Acceptability of different HIV-PrEP modalities among GBMSM and gender-diverse individuals having sex with men in the UK.

BackgroundHIV-PrEP is a key component of HIV combination prevention and has been routinely available through oral formulations (i.e. oral tablets) across sexual health services (SHSs) in the UK since 2020.

Organization of Resilin-like Peptides in Three Dimensions Using Au Nanoparticles.

Nature provides a palette of materials with properties ranging from strong and tough to flexible and elastomeric. Resilin, a protein in insects, can generate resilient elastomers cross-linked at tyrosine residues. These elastomers rival or exceed the properties of synthetic materials, making it desirable to mimic the natural system.