Association of preoperative nocturnal hypoxaemia nadir and fentanyl ventilatory sensitivity in children with obstructive sleep apnoea undergoing general anaesthesia: multicentre clinical cohort study.

Background: Obstructive sleep apnoea (OSA) has been thought to increase the risk of respiratory depression from opioids. The primary aim of this study was to assess whether preoperative hypoxaemia by sleep study pulse oximetry imparts greater opioid sensitivity.

Methods: A multicentre observational cohort study with in-cohort dose randomisation was performed in children 2-8 yr of age with OSA undergoing adenotonsillectomy.

A scoping review on the possible immunometabolic properties of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid.

Circulating levels of 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF), a metabolite derived from dietary furan fatty acids primarily found in marine food sources, have long been recognized as biomarkers for fish intake. However, elevated CMPF levels are also observed in patients with type 2 diabetes or chronic kidney disease and in healthy people associated with a reduced infection risk, suggesting potential bioactive roles in metabolism and immune function. Yet, the possible causal mechanisms behind these associations are unknown.

Development of chitosan coating loaded with solvothermal-prepared cerium oxide for banana preservation.

In this work, cerium oxide nanoparticles prepared through the solvothermal route (sCeO NPs) are integrated into chitosan (CH) matrices to serve as an efficient coating for banana preservation. The morphological, structural, mechanical, and water-barrier properties of nanocomposite films integrated with various sCeO concentrations were investigated to determine the optimal sCeO NPs concentration within the film matrix. Furthermore, the sensory evaluation and physicochemical properties of the coated and uncoated bananas, including visual attributes, peel browning, CO production, firmness, weight loss, ripening rate (based on total soluble solids and titratable acidity), and pH, are considered during storage.

Quantitative mapping of smooth topographic landscapes generated using thermal scanning-probe lithography.

Scanning probe microscopy (SPM) is a powerful technique for mapping nanoscale surface properties through tip-sample interactions. Thermal scanning-probe lithography (tSPL) is an advanced SPM variant that uses a silicon tip on a heated cantilever to sculpt and measure the topography of polymer films with nanometer precision. The surfaces produced by tSPL-smooth topographic landscapes-allow mathematically defined contours to be fabricated on the nanoscale, enabling sophisticated functionalities for photonic, electronic, chemical and biological technologies.