Nanoparticles revolution: The role of gold and chitosan in endodontics irrigation.

The field of endodontic irrigation has seen nanoparticle innovations which offer improved disinfection together with better clinical treatment results. Nanoparticles composed of gold and chitosan show significant antibacterial properties as well as anti-inflammatory characteristics and biocompatibility potential. The photo thermal properties and catalytic properties are limited to gold nanoparticles whereas the natural antimicrobial capabilities and adhesive properties are limited to chitosan nanoparticles.

Tigecycline pharmacodynamics in the hollow fiber system of -complex lung disease, and the utility of MICs and time-kill studies in drug development.

Background: Guideline-based therapy (GBT) drugs for (MAC) lung disease (LD) were chosen in part because they have low MICs. Despite these low MICs, GBT achieves six-month sustained sputum culture conversion in only 43% of patients.

Methods: First, we co-incubated tigecycline with MAC for seven days in time-kill studies and calculated the exposure mediating 50% of maximal effect (E) or EC.

Increased heterozygosity and balancing selection in isofemale generations of Anopheles stephensi under laboratory conditions.

Background: The urban malaria vector, Anopheles stephensi, originally limited to South Asia and the Arabian Peninsula has now expanded to several countries in Africa. Despite the continuous insecticide pressure and changing urban landscapes, An. stephensi has been able to adapt, sustain, and expand.

Profile of tRNA-derived short non-coding RNAs during monocyte differentiation and their role in macrophage survival.

Monocytes, a type of leukocytes, are key players in immune responses, transitioning to macrophages at infection sites. Differentiation, which is crucial for macrophage survival and resistance to apoptosis, is a tightly regulated process. Based on our earlier findings implicating the 5'-fragment of tRNA (5'-HisGUG) in macrophage biology, we specifically focused on these fragments to investigate its regulation during monocyte-to-macrophage differentiation and its role in macrophage survival.

A 14 years overall survival of a patient with stage IV carcinoma of cervix with lung metastasis - A case report of Ayurveda based integrative approach.

Background: Carcinoma of the cervix is a leading cause of cancer-related mortality in women. The commonest metastatic site in cervical cancers is lung. Prognosis of cervical cancer with lung metastasis is very poor.