Selectivity profiles and substrate recognition of Rab-phosphorylating kinases.

The Rab GTPase switch-2 region is a hotspot for post-translational modifications. Its phosphorylation can determine whether individuals develop Parkinson's disease or not. Other modifications of the same region are catalyzed by enzymes from bacterial pathogens when they infect human cells.

MERGE: Multi-faceted Hierarchical Graph-based GNN for Gene Expression Prediction from Whole Slide Histopathology Images.

Recent advances in Spatial Transcriptomics (ST) pair histology images with spatially resolved gene expression profiles, enabling predictions of gene expression across different tissue locations based on image patches. This opens up new possibilities for enhancing whole slide image (WSI) prediction tasks with localized gene expression. However, existing methods fail to fully leverage the interactions between different tissue locations, which are crucial for accurate joint prediction.

Co-design of Active Material and Solid Electrolyte Particulate Phases in Solid-State Battery Composite Electrodes.

The performance of solid-state batteries (SSBs) is strongly influenced by the solid-state cathode architecture, particularly the particle sizes of the active material (AM) and solid electrolyte (SE). While smaller SE particles are known to consistently enhance composite-level effective ionic transport, the underpinning role of the AM particle size remains unclear. Although smaller AM particles are often assumed to enhance the rate capability, some experimental observations have shown conflicting trends.

Nebulized Dexamethasone versus Intravenous Dexamethasone in Prevention of Postoperative Sore Throat: An Interventional Study.

Context: This study investigated the effects of preoperative dexamethasone, administered intravenously or through nebulization, on postoperative sore throat (POST) and glucose regulation in patients undergoing general anesthesia (GA) with endotracheal intubation.

Aims: This study aimed to asses the effectiveness of nebulised versus intravenous dexamethasone in prevention of postoperative sorethroat in patients undergoing GA with endotracheal intubation.

Settings And Design: This study was a prospective, single-blind, randomized controlled trial with a sample size of 138 participants.