Signal Transducer and Activator of Transcription 3 (STAT3) Variant p.K709N Causes Hyper-IgE Syndrome Likely by Impaired STAT3-Dimer Formation.

STAT3-hyper-IgE syndrome (STAT3-HIES) is an inborn error of immunity caused by heterozygous dominant-negative mutations in the signal transducer and activator of transcription 3 (STAT3). In this study, we evaluate the functional relevance of a previously undescribed heterozygous STAT3 variant in a patient with clinical findings of STAT3-HIES. Flow cytometry, quantitative real-time PCR, pull-down assays, native PAGE, DNA-binding ELISA, and 3D-structural data analysis were performed.

Leveraging RAS-mSIN1 interaction to selectively inhibit mTORC2 employing competitive RAS binding peptide: implications in breast cancer metastasis.

The pivotal role of mTORC2 in cancer progression and metastasis underscores its potential as drug target. Despite this, selective inhibition of mTORC2 without affecting mTORC1 represents an unmet need in cancer therapy. We aimed to exploit RAS-mSIN1 interaction for selective mTORC2 targeting.

Hiccups with a Twist: A Rare and Surprising Cause Behind Those Involuntary Spasms.

Hiccups is a reflex consisting of a sudden spasmodic contraction of the diaphragm causing shaking of the inspiratory muscles of the chest and abdomen, followed by the sudden closure of the glottis. Persistent hiccups, i.e.

Is Stretching exercises Superior to Steroids for Sustained Relief in Plantar Fasciitis? Evidence from a Prospective Study.

Introduction: Plantar fasciitis is a prevalent cause of heel pain, especially in middle-aged and older adults. This study compares the short-term and long-term effectiveness of plantar fascia stretching exercises versus corticosteroid injections in improving pain and function.

Materials And Methods: This prospective clinical trial included 100 patients randomly assigned to two treatment groups: One undergoing plantar fascia-specific stretching exercises with anti-inflammatory medications, contrast bath and shoe insole and the other receiving a single corticosteroid injection (Triamcinolone acetonide 1 mL i.

Melorheostosis: A Rare Case Report with Pelvic and Lumbar Involvement.

Introduction: Melorheostosis is an extremely rare, non-hereditary bone disorder characterized by its distinctive radiographic feature of flowing hyperostosis, reminiscent of dripping candle wax, typically appearing unilaterally in long bones. Initially proposed by Leri and Joanny in 1922, the exact cause remains largely speculative, and treatment is primarily symptomatic. This condition predominantly affects a single limb, with a higher incidence in the lower extremities, while axial skeletal involvement is uncommon.