Clinical care of family members of patients with dilated cardiomyopathy.

Genetic family screening following the detection of a pathogenic or likely pathogenic variant in a proband with dilated cardiomyopathy (DCM) remains one of the main applications of genetic testing. While cardiac screening is recommended for all first-degree relatives, the a priori risk among family members varies. Consequently, screening regimens should be tailored according to both genetic and clinical information at the individual and familial level.

Comparison of aquatic system models using outdoor mesocosm data for ecological risk assessment, part I: methodology.

Mesocosm studies are conducted in the context of higher-tier ecological risk assessments (ERAs) to integrate environmental conditions and study species interactions within waterbodies in agricultural landscapes. Aquatic system models (ASMs) could provide tools to extrapolate the dynamics and effects of chemicals observed in mesocosm studies to a wider range of environmental conditions and exposure scenarios. In this paper, we present the methodology of a ring study with four ASMs (Aquatox, CASM, StoLaM+, Streambugs) applied to data from mesocosm studies, while the results of the ring study are presented in a companion paper published alongside this manuscript.

Boron-Functionalized Graphitic Carbon Nitride Materials for Photocatalytic Applications: Effects on Chemical, Adsorptive, Optoelectronic, and Photocatalytic Properties.

Graphitic carbon nitride (gCN, or CN herein) is widely studied as a photocatalyst owing to its ease of synthesis, high stability, and optoelectronic properties. However, its photocatalytic performance often remains limited, and a common approach to tune its function and enhance its performance is by doping. Boron (B) functionalization of CN has showed a potential benefit on photocatalytic performance for several reactions.

Equations for estimating binary mixture toxicity: Methyl-2-chloroacetoacetate-containing combinations.

Mixture toxicity was determined for 30 A+B combinations. Chemical A was the reactive soft electrophile methyl-2-chloroacetoacetate (M2CA), and chemical B was one of 30 reactive or non-reactive agents. Bioluminescence inhibition in was measured after 15-, 30-, and 45-minutes of exposure for A, B, and the mixture (MX) with EC (i.