Structural and dynamic properties of guanosine-analog binding to 2'-deoxyguanosine-II riboswitch: a computational study.

Antibiotic resistance poses a significant global health threat, necessitating the development of novel antibacterial strategies. Riboswitches, particularly those sensing purines, have emerged as promising targets for antibiotic development. In an unconventional approach, we explore the repurposing of antiviral compounds as potential antibacterial agents targeting riboswitches.

PD-1 and ICOS are coexpressed in T follicular helper cells but define three stages of maturation of T follicular regulatory cells.

Humoral responses to infection or vaccination require T cell-B cell interactions. T follicular helper (T) cells drive germinal center (GC) responses by providing help to B cells, whereas T follicular regulatory (T) cells regulate them. Both mature GC-located T and T cells are widely characterized by the expression of ICOS and PD-1.

Body weight trajectory of non-obese asthmatics: Relationship with inhaled corticosteroids maintenance therapy.

It is unclear whether the continuous use of a high dose of inhaled corticosteroids (ICS) could contribute to an unfavorable trajectory in body weight. The objective was to evaluate whether a high dose of ICS used continuously for maintenance therapy increases the risk of an unfavorable body weight trajectory in individuals with asthma and who are not obese. We screened consecutive individuals with chronic respiratory symptoms suggestive of asthma who underwent a medical consultation in any of the 42 public health facilities in the municipality of Jundiaí, Brazil.

Computational Structural Comparison of Toxoplasma gondii CDPK1 and Human BUB1 kinases: Implications for Selective Inhibitor Design.

Toxoplasmosis, affecting one-third of the global human population, urgently requires new therapeutic strategies due to current treatment limitations and drug resistance. Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) is a promising drug target due to its essential role in parasite survival and its presumed unique glycine gatekeeper residue. Aiming at identifying new and selective inhibitors of TgCDPK1, we performed computational structural analyses and unexpectedly found that a human kinase (BUB1), despite having only 14% sequence identity, shares this glycine gatekeeper with TgCDPK1, which initially raised concerns for selective inhibitor development.

Chemical Composition and In Vitro Antibiofilm Action of Varronia curassavica Jacq. (Boraginaceae) Essential Oil: A Promising Natural Agent Against Bacterial Infections.

Antimicrobial resistance is an increasing threat to public health, with alarming estimates of mortality rates. In this context, the clinical properties of Varronia curassavica Jacq. are highlighted due to its biological and pharmacological activities.