Optimized network inference for immune diseased single cells.

Introduction: Mathematical models are powerful tools that can be used to advance our understanding of complex diseases. Autoimmune disorders such as systemic lupus erythematosus (SLE) are highly heterogeneous and require high-resolution mechanistic approaches. In this work, we present ONIDsc, a single-cell regulatory network inference model designed to elucidate immune-related disease mechanisms in SLE.

Humic acid aggregates with laccase and decreases the performance of the enzyme catalytic systems through various mechanisms.

Laccases are among the best-rated enzymes for industrial and environmental applications, yet their use in bioremediation is limited by interference from environmental components like humic acid (HA). This study evaluated HA impact on the oxidation of 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonate (ABTS) and two model pollutants - anthracene and methyl orange - by laccase(-mediator) systems. HA consistently diminished conversion rates, with EC50 values between 5 and 51 mg/L suggesting diverse inhibitory mechanisms.

T cell-specific non-viral DNA delivery and in vivo CAR-T generation using targeted lipid nanoparticles.

Background: Ex vivo chimeric antigen receptor (CAR)-T therapies have revolutionized cancer treatment. However, treatment accessibility is hindered by high costs, long manufacturing times, and the need for specialized centers and inpatient care. Strategies to generate CAR-T cells in vivo have emerged as a promising alternative that could bypass CAR-T manufacturing bottlenecks.

Osteology of Dwarfgobies Eviota and Sueviota (Gobiidae: Gobiomorpharia), With Phylogenetic Inferences Within Coral Gobies.

Eviota and Sueviota are two genera of cryptobenthic fishes of the family Gobiidae commonly known as dwarfgobies, that collectively contain 142 species. Despite thorough descriptions of the variation of their external morphology, little is known about variations on their skeleton. Combining traditional clearing-and-staining technique with computed scanning microtomography, we examined five species of Sueviota and 40 species of Eviota, representing the two major monophyletic groups in the latter genus, the "branched clade" and "unbranched clade," named for their pectoral ray morphology.

Effects of Attentional Focus on Dual-Task Walking Performance in Older and Young Adults.

Walking, often performed automatically, allows for concurrent tasks like carrying objects, but dual-tasks can be challenging for the older adults. As previous search supports the benefits of external focus (EF) over internal focus (IF) of attention in motor tasks, this study investigated attentional effects on dual-task walking performance in young and older adults. A total of 84 healthy participants (42 young adults, 23.