Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.

Introduction: Mutations in SORL1, encoding the sorting receptor Sortilin-related receptor with A-type repeats (SORLA), are found in individuals with Alzheimer's disease (AD). We studied SORLA, carrying a mutation in its ligand binding domain, to learn more about receptor functions relevant for human brain health.

Methods: We investigated consequences of SORLA expression in induced pluripotent stem cell (iPSC)-derived human neurons and microglia, using unbiased proteome screens and functional cell assays.

Estimating a minimum clinically important difference for the Developmental Behaviour Checklist - parent report.

Background: Evaluating the effectiveness of interventions relies on understanding what change in a main outcome is sufficient to be considered meaningful. Our aim was to estimate a Minimum Clinically Important Difference (MCID) for the Developmental Behaviour Checklist, parent-report (DBC-P)- a measure of behavioural and emotional problems in children and adolescents with intellectual disabilities.

Methods: We generated distribution-based estimates through meta-analysis of intervention evaluations using the DBC-P as an outcome measure.

AutoSAS: A new human-aside-the-loop paradigm for automated SAS fitting for high throughput and autonomous experimentation.

The advancement of artificial-intelligence driven autonomous experiments demands physics-based modeling and decision-making processes, not only to improve the accuracy of the experimental trajectory but also to increase trust by allowing transparent human-machine collaboration. High-quality structural characterization techniques (e.g.

Family functioning as a mediator or moderator between child behavioural and emotional problems and maternal psychological distress.

Background: Mothers of children with intellectual disabilities are more likely to show elevated psychological distress, with child behavioural and emotional problems being a significant risk factor. Family Resilience Theory suggests that family relationships are crucial in influencing adaptation to stressors. We investigated whether family functioning mediates or moderates the relationship between child behavioural and emotional problems and subsequent maternal psychological distress.

Optimizing algal harvest interval to enhance the performance of Filamentous Algal Nutrient Scrubbers (FANS) treating agricultural drainage.

This study investigated the impact of harvest frequency on algal biomass productivity and nutrient removal in outdoor, pilot-scale Filamentous Algal Nutrient Scrubbers (FANS) treating river water. The FANS were 12 m in length and received a constant inflow rate of 3 L min and a standing volume of 14 L They were initially seeded with a mixture of NZ native filamentous algae (Oedogonium sp., Cladophora sp.