Neural Control of Goblet Cell Function in the Gastrointestinal Tract.

The mucus layer is an essential physical barrier that protects and lubricates mucosal surfaces in the body. The semi-permeable nature of the mucus layer limits bacterial interactions with the epithelium, while allowing nutrient absorption. Goblet cells (GCs) are specialized epithelial cells with a classical role to synthesize and secrete mucus to maintain the mucus layer.

A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor.

Chronic pain and depression are widely prevalent comorbid conditions with limited safe, yet effective treatments. While μ-opioid receptor (MOR) agonists are effective for treating pain, they are plagued with significant drawbacks, including dependence, addiction, and respiratory depression. The δ-opioid receptor (DOR) offers a promising alternative due to its potential ability to reduce pain but with a reduced side effect profile.