Ultrastrong adhesion to human skin: Calcium as a key regulator of noncovalent interactions.

Calcium is a critical regulator of skin adhesion, stabilizing one of the strongest noncovalent biomolecular interactions ever recorded. Using in vitro and in silico single-molecule force spectroscopy, we demonstrate that calcium ions (Ca) are essential for the ultrastrong binding between the serine-aspartate repeat protein D (SdrD) adhesin and the human skin protein desmoglein-1 (DSG-1), withstanding forces exceeding 2 nanonewtons. Ca ions stabilize both the SdrD complex and the mechanically robust SdrD B-domains, which exhibit unprecedented folding strength.

Photobiomodulation vs. nonsteroidal anti-inflammatory drugs after diode laser excision of lower lip lesions: a case series.

The present study aimed to compare photobiomodulation (PBMT) and the use of a non-steroidal anti-inflammatory drug (NSAID), after surgical removal of lower lip lesions with a high-power diode laser. This was a series of 13 cases, in which all subjects were treated with high-power diode laser (808 nm) in continuous mode, with a power between 2.0 and 2.

Feasibility and Preliminary Results of a Standardized Stair Climbing Test to Evaluate Cardiorespiratory Fitness in Children and Adolescents in a Non-Clinical Setting: The "Hand Aufs Herz" Study.

: Cardiorespiratory fitness (CRF) is of great interest in children and adolescents. Due to the limited availability of cardiopulmonary exercise testing, simple and reliable alternatives are needed. A stair climbing test (SCT) for the assessment of CRF developed at the Department of Pediatric Cardiology of the LMU University Hospital in Munich showed a strong correlation with VOmax.

Preschool Hearing Screening: Nineteen Years of the Coração Delta Project in Campo Maior, Portugal.

: Preschool hearing screening is justified by the risk of late onset hearing loss, the high prevalence of otitis media with effusion in school-aged children, and the critical timing just before children begin formal reading and learn to write. This study describes the results of the annual preschool hearing screening program in Campo Maior from 2007 to 2025 (nineteen years) and correlates the audiological referral to the otoscopy findings by the otolaryngologists. : Retrospective study using clinical records from nineteen years of preschool hearing screening.

Outcomes of transcatheter aortic valve replacement in younger low-risk patients: a comprehensive meta-analysis of efficacy and safety.

Background And Aims: Severe aortic stenosis (AS) was traditionally managed with surgical aortic valve replacement (SAVR). Transcatheter aortic valve implantation (TAVI) emerged as a less invasive alternative, initially for high-risk patients. This meta-analysis evaluates the outcomes of TAVI in younger, low-risk patients, in whom SAVR is currently the gold standard.