The effects of cadmium and high fructose diet on metabolic and reproductive health in female CD-1 mice.

Background: Evaluation of the combined effects of endocrine-disrupting chemicals and dietary factors provides critical information for cumulative health risk assessment. Herein, we investigated the effects of cadmium (Cd) exposure and high fructose (HFr) diet on metabolic and reproductive health in female mice.

Methods: Female CD-1 mice were exposed to cadmium chloride (CdCl) (0.

Physiotherapy students' perceptions of how the Cervical Framework influences their clinical reasoning: A qualitative single case study of a Canadian university.

Background: Neck pain and headaches are highly prevalent, often presenting a challenge for physiotherapists when considering differential diagnoses. For guidance, the International Federation of Manual and Musculoskeletal Physical Therapists (IFOMPT) created the International IFOMPT Cervical Framework. Its purpose is to improve clinical reasoning through various functional objectives and design principles.

Determining the mechanisms that cause woody plants to moderate microclimate in grasslands.

Forests and grasslands experience shifts in woody plant cover creating a continuum of woody plants across space. Global change accelerates this, causing many ecosystems to experience the redistribution of woody plants. There is growing interest in understanding how these ecological changes influence ecosystem function including climate regulation.

An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS.

To uncover molecular determinants of motor neuron degeneration and selective vulnerability in amyotrophic lateral sclerosis (ALS), we generated longitudinal single-nucleus transcriptomes and chromatin accessibility profiles of spinal motor neurons from the SOD1-G93A ALS mouse model. Vulnerable alpha motor neurons showed thousands of molecular changes, marking a transition into a novel cell state we named 'disease-associated motor neurons' (DAMNs). We identified transcription factor regulatory networks that govern how healthy cells transition into DAMNs as well as those linked to vulnerable and resistant motor neuron subtypes.

The PARCS Pilot Study Randomized Controlled Trial: Feasibility and Acceptability of a Park-Based Exercise Program Led by Peer Specialists for Peers with Serious Mental Illness.

Adults with serious mental illness (SMI) die decades early, mostly from heart disease. Few park-based exercise interventions have been tested, none focused on SMI. The study (NCT05293587) tested a 6-week exercise intervention (INT; 45 min park-based exercise led by a certified peer specialist (CPS) 3 days/week) vs.