Decision-making experiences in gonadectomy and gonadal tissue cryopreservation for adolescents/young adults and parents of individuals with differences of sex development: A qualitative study.

Background: Our institution offers experimental gonadal tissue cryopreservation (GTC) at the time of prophylactic gonadectomy for malignancy risk for individuals with differences of sex development (DSD). Decisions about GTC are challenging for numerous reasons: the experimental nature of the procedure and uncertainty of future reproductive success, costs, possibility of heritability of the condition, and possible discordance between gender identity and germ cells.

Objective: In this qualitative study, we sought to examine gonadectomy and GTC decision-making experiences of parents and patients to inform future healthcare needs in DSD.

Perspectives From Adolescents and Young Adults With Klinefelter Syndrome on Testosterone Supplementation and Fertility.

Context: Infertility and testicular dysfunction are typical features of Klinefelter syndrome (KS; 47,XXY). KS affects ∼1:600 male births, making it the most common chromosomal aneuploidy. As more adolescent and young adult (AYA) patients with KS seek care, it becomes increasingly important to investigate their understanding of information about testosterone supplementation and infertility.

Neanderthal coasteering and the first Portuguese hominin tracksites.

Multiple sources of evidence for the systematic use of coastal ecosystems and resources by Neanderthals are known. Fossil hominin footprints offer direct portraits of individual or social group presence and locomotor behavior, and interspecific interactions, in the coastal ecospace. Here we describe the first two hominin tracksites found in the southwestern most region of Europe.

Finding acceptance: How adolescents and young adults with Klinefelter Syndrome navigate identity, disclosure, and support.

Klinefelter syndrome (KS; 47, XXY) is the most common chromosomal aneuploidy, affecting ~1:600 male births. Due to recent technological advances, KS is diagnosed more often in young individuals. This emerging population of adolescent and young adult (AYA) patients with KS seeking care makes it increasingly important to understand the unique experiences and perspectives of these individuals.

Fertility in differences of sex development patients.

Management of differences of sex development (DSD) continues to evolve, with increased attention to fertility. Knowledge gaps remain among providers and patients about fertility potential and options for fertility preservation. It is complicated, requiring individualized assessment.