Standing under pressure: hemodynamic effects of abdominal compression type and intensity in healthy adults.

Introduction: Abdominal compression is recommended to manage orthostatic intolerance in dysautonomia, but the hemodynamic effects of different compression parameters remain poorly understood. This study investigated how surface area and pressure magnitude of abdominal compression affect blood pressure and heart rate responses during active stand tests in healthy volunteers. Understanding how abdominal compression modulates hemodynamics during standing in healthy individuals will help us better understand how compression can be optimized to benefit those with dysautonomia.

Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial.

Background: Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo-hMSCs) may reduce neuroinflammation and improve motor symptoms.

Objectives: To evaluate the efficacy of repeated intravenous doses of 10 × 10/kg allo-hMSCs in improving motor symptoms in patients with PD (PwP).

Projecting stream water quality using Weighted Regression on Time, Discharge, and Season (WRTDS): An example with drought conditions in the Delaware River Basin.

Future water availability depends on understanding the responses of constituent concentrations to hydrologic change. Projecting future water quality remains a methodological challenge, particularly when using discrete observations with limited temporal resolution. This study introduces Weighted Regression on Time, Discharge, and Season for Projection (WRTDS-P), a novel, computationally efficient method that enables the projection of daily stream water quality under varying hydrologic conditions using commonly available discrete monitoring data.

Automated system of analysis to quantify pediatric hip morphology.

Developmental dysplasia of the hip (DDH), a developmental deformity with an incidence of 0.1-3.4%, lacks an objective and reliable definition and assessment metric by which to conduct timely diagnosis.