Analysis of Tissue Staining With 1% Methylene Blue Solution After Enucleation of Odontogenic Keratocyst.

Background: Odontogenic keratocyst (OKC) treatment often involves enucleation followed by peripheral ostectomy to reduce recurrence. However, identifying bone areas containing epithelial remnants remains a surgical challenge. The intraoperative use of 1% methylene blue solution has been proposed to delineate residual epithelial tissue.

Oral Verruciform Xanthoma as a Manifestation of Chronic Graft-Versus-Host Disease in Fanconi Anemia: A Rare Case Report.

Background: Oral verruciform xanthoma (OVX) is an uncommon benign epithelial lesion, typically observed in otherwise healthy individuals. It has occasionally been reported in association with chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). To date, only 12 cases of OVX associated with cGVHD have been reported in the literature.

Acquired oral syphilis: epidemiology, diagnostic pitfalls, and treatment strategies.

Objective: Acquired oral syphilis (AOS) remains a neglected yet clinically significant manifestation of Treponema pallidum infection, frequently overlooked in routine diagnostic workflows. This review examines the epidemiology, pathogenesis, clinical features, diagnostic challenges, and management of AOS, highlighting its relevance in contemporary clinical practice. A diagnostic algorithm is proposed.

Clinical and aetiological factors in spongiotic gingival hyperplasia.

Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a rare gingival lesion characterized by exuberant epithelial proliferation. Its etiology remains unclear, with few studies exploring its clinical and histopathological features. This retrospective study aimed to analyze the demographic, clinical, and etiological characteristics of LJSGH across 13 diagnostic centers in Latin America.

Dento-Craniofacial Features of Tricho-Dento-Osseous Syndrome: A Systematic Review and Meta-Analysis.

Aims: Tricho-dento-osseous syndrome (TDOS), a rare autosomal dominant condition caused by mutations in DLX3, is characterized by abnormalities in teeth, bone, and hair. This systematic review and meta-analysis summarized the most frequently reported dento-craniofacial features of TDOS.

Methods: Searches were undertaken in five databases supplemented by manual scrutiny and a gray literature search.

Oral viral, fungal, and bacterial infections linked to comorbidities: A case series from a Brazilian referral center.

Background: Oral infections exhibit variability in their causative agents and clinical presentations, underscoring the necessity of accurate diagnosis for effective management. Despite extensive documentation globally, data on these infections from Brazil remain scarce. This study aimed to assess the occurrence, clinical features, and differential diagnosis of oral viral, fungal, and bacterial infections at a single center in southern Brazil.

Heterotopic gastrointestinal cyst of the oral cavity: A rare clinical report and literature review.

This study reports a case of oral heterotopic gastrointestinal cyst (HGIC) and provides a comprehensive analysis of its demographic distribution, clinicopathological features, and treatment outcomes based on a literature review. The case involved a 6-year-old boy with a sublingual HGIC, with detailed documentation of the clinical presentation, imaging findings, surgical management, and histopathological features. Searches were conducted in PubMed, Scopus, Web of Science, Embase, and LILACS, supplemented by manual searches/gray literature.

Ameloblastoma on YouTube: content analysis and strategies to address misinformation.

Purpose: Internet platforms, such as YouTube, play a significant role in disseminating health information. This study assessed the quality and reliability of YouTube videos related to ameloblastoma.

Methods: This cross-sectional study examined videos using the Global Quality Scale (GQS) to assess content quality and the DISCERN tool to determine reliability.

Assessment of salivary biomarkers in psoriasis: a comprehensive scoping review.

Objective: To map the evidence on altered salivary biomarkers in individuals with psoriasis.

Study Design: A comprehensive literature search was conducted across six databases and gray literature sources using keywords related to psoriasis and salivary biomarkers, with no restrictions on time or language, up to November 2024. Studies evaluating salivary biomarkers in humans with psoriasis were considered eligible.

Oral Melanoma in Older Adults: Epidemiology, Molecular Landscape, and Treatment Strategies.

Oral melanoma is an aggressive neoplasm arising from melanocytes in the mucosal epithelium, accounting for 0.2%-0.8% of all melanomas.

Mandibular Bone Imaging Assessment in Individuals With Rheumatoid Arthritis: A Comparative Cross-Sectional Study.

Objective: To assess the risk of low bone mineral density (BMD), evaluated by mandibular cortical index (MCI), W-index (WI), and the continuity of the mandibular canal cortices in rheumatoid arthritis (RA) patients in comparison with healthy subjects.

Material And Methods: A retrospective and comparative study was conducted in individuals diagnosed with rheumatoid arthritis (Study Group-SG) and healthy individuals without comorbidities (Control Group-CG). MCI, WI, and the continuity of the mandibular canal cortices were evaluated by two experienced observers.

An exuberant case of uremic stomatitis in an older adult.

Objective: To report the case of an older adult with uremic stomatitis.

Background: Uremic stomatitis is a rare condition, with only 57 cases documented in the literature. Gerodontologists may be unfamiliar with this condition.

Strawberry gingivitis as an initial presentation of granulomatosis with polyangiitis in an older adult.

Objective: To describe a rare case of granulomatosis with polyangiitis (GPA) in an older adult in light of the existing literature.

Background: GPA is a potentially life-threatening multisystem necrotising vasculitis, characterised by a spectrum of oral mucosal lesions that present diagnostic challenges.

Materials And Methods: A 76-year-old female patient presented with asymptomatic granular and haemorrhage swelling ("strawberry" gingivitis) affecting the upper and lower anterior and posterior gingivae.

Oral and Maxillofacial Manifestations of Kallmann Syndrome: A Systematic Analysis of the Literature.

Aims: Kallmann syndrome (KS) is a rare genetic disorder characterized by congenital hypogonadotropic hypogonadism and varied clinical features. Despite its recognition, the oral and maxillofacial manifestations remain poorly understood. This study synthesized clinical aspects and management of KS-related oral and maxillofacial alterations.

Leukemia and Lymphoma Mimicking Periapical Conditions Resulting in Endodontic Treatment: A Systematic Review.

Introduction: Leukemia and lymphoma mimicking periapical conditions can lead to significant diagnostic pitfalls. Guidance for endodontists in managing such cases is barely explored. This systematic review aimed to summarize the clinicopathologic, imaging, and management aspects of leukemia/lymphoma that mimicked periapical conditions and resulted in endodontic treatment.

Cystic Lesions and Odontogenic Tumors in Older People: A Brazilian Multicenter Study.

Background: Some odontogenic cysts (OCs) and odontogenic tumors (OTs) are infiltrative and often recur, causing bone destruction and tooth loss. In the elderly, in particular, these injuries cause significant morbidity, making rehabilitation difficult and compromising the quality of life of these individuals. Objective: To determine the prevalence and demographic characteristics of OCs, non-odontogenic cysts (NOCs), and OTs diagnosed in an elderly Brazilian population (≥60 years).

Mandibular bone imaging assessment in thalassemia - a systematic review.

Objective: This systematic review aimed to verify if individuals with thalassemia present changes in radiomorphometric indices and fractal analysis that can be accessed using panoramic radiographs.

Material And Methods: Observational studies that evaluated cortical and trabecular bone patterns in dental routine radiographs were selected from six bibliographic databases. Risk of bias was analyzed using the Joanna Briggs Institute Critical Appraisal Checklists.

Tooth loss from the perspective of studies employing a life course approach: a systematic review.

The life course approach scrutinizes factors that shape the development of diseases over time. Tooth loss, which is influenced by social, behavioral and biological factors, can occur at various stages of life and tends to become more prevalent in later years. This systematic review examined the influence of socioeconomic, psychosocial, biological and behavioral adversities in life on the likelihood of tooth loss.

Immunohistochemistry and RT-PCR as ancillary tools in the diagnosis of acquired oral syphilis.

Objective: To investigate Treponema pallidum detection using immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) assays in acquired oral syphilis (AOS).

Materials And Methods: Thirty-seven paraffin-embedded tissue specimens of AOS (32 secondary and five primary) were analyzed, integrating double-positive serological results with clinicodemographic and histopathological data. T.

Primordial Odontogenic Tumor: A Review of the Literature and Report of Three New Patients.

The primordial odontogenic tumor (POT) is a rare mixed odontogenic tumor composed of mesenchymal cells, columnar odontogenic epithelium, and fibromyxoid stroma affecting the posterior mandible of children and adolescents. Herein, we report 3 patients with POT and the clinicopathological features of POT previously reported in the literature. A 12-year-old, 19-year-old, and 4-year-old patient presented an asymptomatic swelling in the posterior maxilla and posterior mandible.

Histiocytic sarcoma affecting the oral cavity: a clinical, pathologic and molecular study.

Objective: To investigate the clinicopathological, immunohistochemical and molecular features of histiocytic sarcomas affecting the oral cavity.

Methods: Pathology files of two institutions were searched for cases of histiocytic sarcoma, and new H&E-stained slides and immunohistochemistry reactions evaluated for diagnosis confirmation. Molecular screening for KRAS and PIK3CA mutations was performed through polymerase chain reaction (PCR) followed by Sanger sequencing.

Clinicopathologic and imaging features of odontogenic myxomas: a multi-institutional study.

Purpose: This study aims to report clinicopathologic and imaging features of odontogenic myxomas (OM), highlighting uncommon findings.

Methods: Clinicopathologic and imaging data of OMs diagnosed in the five Brazilian diagnostic pathology centers were collected and analyzed.

Results: The series comprised 42 females (68.

Uremic Stomatitis: A Latin American Case Series and Literature Review.

Background: Uremic stomatitis is often unfamiliar to healthcare professionals. This study presents five cases of uremic stomatitis, providing a comprehensive analysis of their demographic distribution, clinicopathological features, and management strategies based on existing literature.

Methods: Data were collected from centers across Brazil, Argentina, Venezuela, and Mexico.