Therapeutic Sunbathing in Yoga and Naturopathy Hospitals: Establishing National Standards through the Delphi Methodology.

Background: Sunlight offers significant health benefits; however, its therapeutic use among yoga and naturopathy physicians varies across India owing to differences in state regulations and training patterns. This study aimed to establish consensus-based guidelines for therapeutic sunbathing using the Delphi method.

Methods: This three-round Delphi study enrolled 25 yoga and naturopathy physicians, after obtaining ethical approval and informed consent.

A systematic review of user-based usability testing practices in self-care mHealth apps.

Background: Self-care mobile health (mHealth) apps empower users to manage their health independently by supporting symptom tracking, medication adherence, and lifestyle changes. Given the limitations of mobile platforms, such as small screens and limited input capabilities, usability is a critical factor influencing the successful adoption of these apps.

Methods: This article presents a systematic review of user-based usability testing practices in self-care mHealth applications.

Reactive Oxygen Species-Responsive Polymeric Chloroquine Nanogel for Targeted Oral Therapy of Ulcerative Colitis.

Targeted drug delivery remains a critical challenge in the treatment of ulcerative colitis, as the side effects of current systemic therapies often outweigh their therapeutic benefits. In this study, we developed a reactive oxygen species (ROS)-responsive nanogel system that releases polymeric chloroquine (PCQ), a macromolecular derivative of hydroxychloroquine (HCQ), for localized treatment of ulcerative colitis. The initial nanogel formulation, measuring 183 nm in size with a surface charge of +13 mV, was synthesized via RAFT polymerization using a thioketal dimethacrylate cross-linker to demonstrate ROS-triggered degradation, physicochemical stability in simulated gastrointestinal fluids, favorable biocompatibility, and preferential accumulation in inflamed colonic tissue.

Experimental and computational approach to develop Rosmarinic acid against insulin resistance in the treatment of diabetes mellitus via PPAR-γ agonism.

From past to the present, plants and trees have benefited humans in many ways. As technology advanced the biological properties of plants are much more explored especially by the pharma industry. Rosemary plant has gained attention as a phytoconstituent-rich herb that may help to manage diabetes mellitus (DM), however, exact mechanism of action is still unknown.

Computational insights and experimental breakthroughs in identifying next-generation acetylcholinesterase inhibitors.

The study aimed to identify the potential acetylcholinesterase (AChE) inhibitors for effective Alzheimer's treatment from existing FDA-approved drugs through a drug repurposing technique via computational tools. Further, to evaluate the anti-Alzheimer's potency of the identified drug with the help of a suitable drug delivery system through in vivo pharmacological studies. The molecular docking and dynamics simulation studies indicated that letrozole has a significant binding affinity of -9.