Patient and Health Professional Perceptions of the Assessment, Diagnosis and Management of Acute Charcot Neuro-Osteoarthropathy at a Regional Australian Health Service.

Background: Acute Charcot neuroarthropathy (CN) is a rare but serious complication of diabetes that requires timely diagnosis and evidence-based management to prevent long-term disability. In regional or rural settings, delivering evidence-based care is particularly challenging due to systemic and contextual barriers.

Objective: To explore the perceptions of patients and health professionals about assessment, diagnosis and management of acute CN in a regional Victorian health service.

Multi-isotope biographies and identities of victims of martial victory celebrations in Neolithic Europe.

Skeletons showing multiple instances of unhealed trauma and isolated skeletal segments of severed left upper limbs have been documented in the Neolithic sites of Achenheim and Bergheim (northeastern France, approximately 4300 to 4150 cal BCE), providing tantalizing evidence of war-related practices of overkill, mutilation, and/or trophy taking. Here, we conduct an innovative multi-isotope reconstruction of the biographies of the "victims" and other individuals from the region that were given normative funerary treatments (nonvictims). A total of 82 humans are analyzed, together with 53 animals and 35 modern plants to establish regional isotope baselines.

Feasibility of scaling-up an evidence-based physical activity behaviour change intervention into routine ambulatory hospital care: a retrospective implementation evaluation using the RE-AIM framework.

Background: Scaling up evidence-based interventions to improve physical activity (PA) is important for enhancing health outcomes. The Healthy4U (H4U) program, initially successful in improving PA and health outcomes among ambulatory hospital patients, was expanded from one regional hospital to five rural hospitals. This study retrospectively examines the feasibility of implementing H4U at Scale (H4U-AS) over 12 months.

Myosin-dependent short actin filaments contribute to peripheral widening in developing stereocilia.

Stereocilia, the actin-based mechanosensory protrusions of inner ear sensory hair cells, require precise dimensional control for proper mechanotransduction, yet the mechanisms governing actin assembly during development remain unclear. Their size and shape are determined by a stable core of long, parallel, unbranched filamentous (F-) actin. We find that during stereocilia widening, which is a key process for function and stability, newly expressed actin first integrates at the tip, then along the periphery of the core.

Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity.

Stereocilia are rod-like mechanosensory projections consisting of unidirectionally oriented actin filaments that extend into the inner ear hair cell cytoskeleton, forming dense rootlets. Taperin (TPRN) localizes to the narrowed-down base of stereocilia, where they pivot in response to sound and gravity. We show that TPRN-deficient mice have progressive deafness characterized by gradual asynchronous retraction and fusion of outer and inner hair cell stereocilia, followed by synaptic abnormalities.