Anterior Versus Posterior Insular Epilepsy: Correlations with Semiology Based on Stereoelectroencephalography.

Objective: To characterize insular seizure semiology and correlate with stereoelectroencephalography (SEEG) seizure onset in a well-defined cohort, in particular examining differences between anterior and posterior insular seizures.

Methods: We documented all semiological signs and the timing of emergence for 45 patients with SEEG-confirmed insular epilepsy, along with the precise location of the seizure onset zone (SOZ) within the insula. Semiological signs and other non-invasive data were compared between those with anterior and posterior insula SOZ, with more detailed insular subregion description when appropriate.

Multifractal spatiotemporal dynamics in human epileptiform stereoelectroencephalography recordings.

Multifractal formalism introduces an invaluable framework for the investigation of nonlinear, scale-invariant features across multiple time scales in non-stationary time series data.In this context, we sought to explore multifractal features defining spatiotemporal correlations in seizure activity, by applying multifractal detrended fluctuation analysis (MFDFA) to stereoelectroencephalography (sEEG) recordings from five patients with refractory, focal temporal epilepsy, who underwent subsequent surgical removal of the temporal lobe and achieved seizure freedom.To the best of our knowledge, we are the first to report evidence for a multifractal architecture underscoring sEEG-recorded epileptiform signals, suggesting a fundamental propensity for scale-invariance in electrophysiological human brain recordings.

Simultaneous Presentation of Cutaneous Waldenström Macroglobulinemia and Acalabrutinib-Related Toxicity.

Waldenström macroglobulinemia (WM) is a rare B-cell lymphoplasmacytic lymphoma associated with clonal IgM gammopathy, comprising 1%-2% of hematological malignancies. The clinical presentation exhibits diverse cutaneous manifestations, including paraproteinemia-related effects, autoimmune phenomena, and neoplastic cell infiltration. Next-generation Bruton tyrosine kinase inhibitors, such as zanubrutinib and acalabrutinib, have revolutionized WM treatment by enhancing selectivity but are associated with various dermatologic lesions.

Genotype-Specific Electroretinogram Signatures in : Implications for Neurodegeneration Models Using Backgrounds.

serves as a powerful model for studying neurodegenerative diseases, often employing the GAL4-UAS system for targeted gene expression. Electroretinograms (ERGs) provide a robust functional readout of neuronal integrity and are increasingly used to assess disease progression and therapeutic interventions in these models. However, the genetic background upon which these models are built, particularly the widely used white-eyed mutant, can significantly influence baseline ERG characteristics.

Morphology and properties of pyrite nanoparticles obtained by pulsed laser ablation in liquid and thin films for photodetection.

This work reports the synthesis of pyrite (iron disulfide (FeS)) nanoparticles (NPs) of different morphologies using pulsed laser ablation in liquid (PLAL) in different organic solvents. The impact of the solvent on the morphological, compositional, and optical properties of the synthesized NPs is investigated by techniques such as transmission electron microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, and ultraviolet-visible spectroscopy. The morphology of the NPs in different solvents varied from spherical, rice-like to rod-like particles which demonstrates the effect of the solvent on the morphology/composition of NPs synthesized by PLAL.