Heterogeneity in Effects of Automated Results Feedback After Online Depression Screening: Secondary Machine-Learning Based Analysis of the DISCOVER Trial.

Background: Online depression screening tools may increase uptake of evidence-based care and consequently lead to symptom reduction. However, results of the DISCOVER trial suggested no effect of automated results feedback compared with no feedback after online depression screening on depressive symptom reduction six months after screening. Interpersonal variation in symptom representation, health care needs, and treatment preferences may nonetheless have led to differential response to feedback mode on an individual level.

Social bias blind spots: Attractiveness bias is seemingly tolerated because people fail to notice the bias.

Discrimination remains a key challenge for social equity. A prerequisite for effective individual and societal responses to discrimination is that instances of it are detected. Yet, prejudice and discriminatory intent are rarely directly observable and the presence of discrimination has to be inferred from circumstantial evidence, such as the over- or underrepresentation of certain individuals (i.

Effectiveness of Pyridoxal-5'-Phosphate in PNPO Deficiency: A Systematic Review.

Pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency is an ultrarare inherited neurometabolic disease, characterized by primarily neonatal-onset B6-responsive epileptic encephalopathies. Treatment often requires sustainable access to high-quality pyridoxal-5'-phosphate (PLP, i.e.

Gait abnormalities in children with FOXP1 syndrome: A case series.

FOXP1 syndrome is a neurodevelopmental disorder caused by mutations or deletions in the Forkhead Box Protein 1 (FOXP1) gene. It is characterized by intellectual disabilities, language difficulties, autism spectrum disorder, congenital anomalies and motor impairments.Walking difficulties have been reported, but specific gait impairments have not previously been described.