Clinical, Radiological, and Molecular Insights into Extracranial Metastases from Adult Gliomas.

Background: Extracranial metastases from adult gliomas cause diagnostic and therapeutic challenges and are generally poorly investigated. The aim of this study was to provide clinical and molecular insights into glioma metastasis.

Methods: Our cohort consisted of tumor tissue from 16 glioma patients with metastasis (14 glioblastomas and 2 lower-grade gliomas).

The importance of integrating surgical resection into preclinical glioblastoma modeling.

Glioblastoma remains a challenging tumor in terms of clinical management with limited progress made since the standard of care was established in 2005. Maximal safe surgical resection, a cornerstone of the standard of care regimen, is a major determinant in patient outcome. However, this key clinical parameter is generally not accounted for in preclinical models, which are often used to provide a rationale for early phase clinical trials.

The concept, intention, and evaluation of the term treatment-refractory meningioma.

Background: Treatment-refractory meningioma is a widely used term but lacks standardized criteria, impairing research comparability and treatment evaluation. The aim of this study was to assess the heterogeneity of patient populations labeled as treatment-refractory and to explore recommendations for better consistency.

Methods: We systematically reviewed 69 studies published before 2024 and analyzed individual participant data from 15 cohorts (n = 211) that included treatment-refractory patients who underwent experimental therapy with somatostatin receptor (SSTR)-targeted therapies.

"This Disease Is a Verdict You Must Live With for the Rest of Your Life": Experiences and Perspectives From People Living With Adult-Onset Myotonic Dystrophy Type 1.

Myotonic dystrophy type 1 (DM1) is a progressive, multisystemic neuromuscular disease. DM1 has a biopsychosocial impact, causing physical and cognitive impairment and limitations in activity and participation as well as having social consequences. The aim of our study was to investigate experiences of and perspectives on living and coping with adult-onset DM1 to inform future targeted rehabilitation services.

Advancing CNS tumor diagnostics with expanded DNA methylation-based classification.

DNA methylation-based classification is integral to contemporary neuro-oncological diagnostics, as highlighted by the current World Health Organization (WHO) classification of central nervous system (CNS) tumors. We introduce the Heidelberg CNS Tumor Methylation Classifier version 12.8 (v12.