Introduction: For rare skin cancers, few data exist on the outcome of systemic therapies, particularly immune checkpoint inhibition (ICI). The present study analysed the real-world use of different systemic therapies including ICI, and its outcome in patients with advanced rare skin cancers.
Methods: This retrospective multicenter study included patients who received systemic therapy for advanced, non-resectable cutaneous angiosarcoma (AS), Kaposi sarcoma (KS), pleomorphic dermal sarcoma (PDS), or cutaneous adnexal carcinoma (CAC).
Importance: Primary hyperparathyroidism (PHPT) is linked to insulin resistance, glucose intolerance, and diabetes. Whether parathyroidectomy is associated with lower risk of diabetes has not been evaluated in a large cohort.
Objective: To examine the independent association between parathyroidectomy and the risk of incident diabetes in patients with PHPT.
JAMA Netw Open
August 2025
Importance: Documentation burden is associated with clinician burnout. To address documentation burden, Mass General Brigham (MGB) in Somerville, Massachusetts, and Emory Healthcare in Atlanta, Georgia, have piloted ambient documentation technology (ADT), which develops artificial intelligence-drafted clinical notes from clinician-patient conversations.
Objective: To examine the prevalence of ADT use and its association with clinicians' experience of documentation burden and burnout before and after use.
Objectives: Adrenal incidentalomas (AI) have been increasingly detected with the widespread use of cross-sectional imaging. This study aimed to evaluate the clinical characteristics of AI and mild autonomous cortisol secretion (MACS) in an Asian population.
Methods: Health records of consecutive patients referred to medical and surgical endocrine clinics from June 2012 to May 2019 for AI at a tertiary institution were analyzed.