Superficial parasternal intercostal plane blocks with liposomal bupivacaine did not significantly reduce opioid use after cardiac surgery: a randomized clinical trial.

Background: Acute pain after cardiac surgery via median sternotomy is commonly managed with multimodal analgesia, but optimal regional techniques remain uncertain. Superficial parasternal intercostal plane (SPIP) blocks have shown promise for postoperative pain control, with the use of catheters extending these benefits up to three days. This study evaluated the efficacy of single-injection SPIP blocks with liposomal bupivacaine in reducing opioid consumption following cardiac surgery.

Ultrafast carrier dynamics of mono- and few-layer WSthrough NaCl assisted chemical vapor deposition growth.

NaCl has widely been used as a seeding promoter for chemical vapor deposition of large-scale 2D transition metal dichalcogenides. In this work, we report a study of the influence of NaCl on the growth and optical properties of layered CVD-grown WSusing steady-state and time-resolved Kerr rotation measurements at room temperature. Strong photoluminescence (PL) signals from single flakes grown with a low NaCl content indicates direct band-gap emission, whereas flakes grown with higher amounts of NaCl exhibit red-shifted, weaker PL.

[Ga]Ga-NODAGA-RGD post MI reflects activated fibroblasts rather than angiogenesis.

Purpose: Angiogenesis is crucial in myocardial healing after myocardial infarction (MI). The αβ-integrin, a key regulator of angiogenesis, is targeted by RGD-based PET tracers like [Ga]Ga-NODAGA-RGD. Yet, angiogenesis imaging using RGD-based tracers is seriously hampered by the lack of true specificity of the αβ-integrin for angiogenic cells.

Dexmedetomidine produces more sleep-like brain activity compared to propofol.

Introduction: Dexmedetomidine is a selective α-adrenergic agonist used as an anesthesia adjunct to produce a state of sleep-like sedation. However, how brain activity compares quantitatively during dexmedetomidine anesthesia to that during natural sleep, and thus just how "sleep-like" dexmedetomidine anesthesia is, remains unclear. Previously, we showed that the general anesthetic propofol is associated with changes in connectivity and cortical network structure comparable to those observed during sleep.

Wearable peripheral nerve stimulator reduces essential tremor symptoms through targeted brain modulation.

Background: Essential tremor (ET), the most common movement disorder in adults, presents with involuntary shaking of the upper extremities during postural hold and kinetic tasks linked to dysfunction in the cerebello-thalamo-cortical network. Recently, transcutaneous afferent patterned stimulation (TAPS), applied through a wrist-worn device, has emerged as a non-invasive treatment for medication-refractory ET. However, its mechanism remains unclear.