Type I interferon limits central nervous system autoimmunity by modulating the microRNA-21-FOXO1 axis in pathogenic T helper 17 cells.

IFN-β, a type I interferon, has been used as a first-line therapy for patients with multiple sclerosis (MS) for more than 30 years; however, the cellular and molecular basis of its therapeutic efficacy remains unclear. Here, we first used experimental autoimmune encephalomyelitis (EAE), a mouse model for MS, to show that the therapeutic effects of IFN-β were associated with a down-regulation of microRNA-21 (miR-21) and pathogenic T17 (pT17) cells. In vitro experiments demonstrated that genetic knockout of miR-21 directly inhibited pathogenic T17 cell differentiation.

Comparison of immunohistochemical HER2 low detection in breast cancer using two antibodies assays in an interlaboratory study.

The identification of HER2-low expression has become critical for breast cancer treatment decisions in recent years. We retrospectively assessed the prevalence of HER2-low in 2270 samples using different immunohistochemistry (IHC) assays in three reference laboratories (LAB) of the same pathology network in Brazil. From 2021 to 2023, LAB A and LAB B routinely used Dako anti-c-erbB-2 polyclonal antibody (A0485) on Autostainer Link 48 Agilent/Dako and had HER2-low prevalence of 16 to 19%.

Tire road wear particles, microplastics and metals in sediment of stormwater detention basins: co-occurrence and ecological risk assessment.

Tire road wear particles (TRWP) and microplastics (MP) are increasingly present in the environment due to anthropogenic sources like industrial activities and road traffic. Their load is high in urban sediments and more specifically in stormwater management infrastructure such as detention basins. Eleven detention basins featured by contrasting land uses (industrial, urban, agricultural, and heterogeneous) were sampled in a French metropolitan city to examine how land use influences the presence of TRWP, MP, and metals in these basins.

Colloidal processing as a successful alternative to produce PLA/Mg composites with tailored mechanical and biodegradation properties.

The PLA/Mg composite has been proposed as a promising new biodegradable biomaterial with interesting properties for use in a number of biomedical applications. However, its processing is still highly problematic mainly due to its high reactivity and biodegradability. Recently the benefit of a new processing route based on a colloidal approach has been proposed based on the particle surface modification with different polyelectrolytes.

Tuning Biodegradation and Physicochemical Features of PLA/HAp Biomaterials by Incorporating Nanofibrillated Cellulose Through a Colloidal Processing Route.

Biomaterials play a fundamental role in providing a porous structure that mimics the natural structure of human bone and serves as a support while tissue regenerates. With the use of biodegradable materials, it is possible to avoid unnecessary second surgeries for implant removal. The main objective of this article has been focused on modifying the degradation rate of a biodegradable composite material based on polylactic acid (PLA) reinforced with hydroxyapatite (HAp) by incorporating nanofibrillated cellulose (NFC), capable of tuning the porosity within the matrix.