Resistance profile of Escherichia colis trains isolated at the main hospital in Dakar retrospective study over 10 years.

Objectives: The objective of this work is to describe the trends in antimicrobial resistance profiles of E. coli strains isolated from various clinical specimens at the main hospital in Dakar over a ten-year period.

Methodology: This was a retrospective, cross-sectional descriptive and analytical study over 10 years 2012–2021] of all isolated at the HPD laboratory.

WHO-Point prevalence survey of antibiotic use in a Senegalese tertiary care hospital.

The inappropriate use of antibiotics in human medicine is one of the primary causes of antimicrobial resistance. The objective of this study was to estimate the prevalence of antibiotic use at Dakar Principal Hospital and to identify factors associated with the prescription of broad-spectrum antibiotics. This cross-sectional study, conducted according to the WHO-point prevalence survey method, included all patients hospitalized in acute care wards who presented at 8:00 AM on the day of the survey.

Rhino-orbital-cerebral mucormycosis in diabetic ketoacidosis: A classic clinical presentation still unknown in Senegal.

Rhino-orbital-cerebral mucormycosis (ROCM) is an invasive mycosis caused by fungi of the order Mucorales. It mainly affects patients with uncontrolled diabetes. This case report concerns a 27-year-old woman with diabetic ketoacidosis who presented with a large erythematous plaque localised in the right orbitofrontal region with exophthalmos and patches of necrosis that rapidly led to death within 3 days before the diagnosis of ROCM due to , the causal agent.

SARS-CoV-2 conjugate vaccine elicits robust immune responses that can protect against evolving variants.

The SARS-CoV-2 pandemic necessitated effective vaccines that can endure antigenic mutations. Here we demonstrate highly immunogenic conjugate vaccines that elicit broad cross-neutralization to variants of concern (VOC) in animal studies. By utilizing protein-protein conjugation and Toll-Like Receptor (TLR) agonist adjuvants we achieve enhanced immunogenicity compared to unconjugated equivalents.