Antidesmoglein 1 and 3 serum IgG and positivity by direct immunofluorescence microscopy is associated with relapse in pemphigus in a prospective bicontinental study.

Background: Prospective studies identifying immunological parameters that can predict clinical relapse in pemphigus are scarce.

Objective: To periodically assess immunological parameters in patients with pemphigus vulgaris and foliaceous in remission to understand immunological events preceding clinical relapse.

Methods: A total of 105 patients were included.

Primary intracerebral pleomorphic liposarcoma in a young male.

Liposarcoma is the commonest soft tissue neoplasm, usually located in the deep soft tissue of the limbs. The central nervous system (CNS) as the primary site is exceedingly rare. We report a 35-year-old male patient who presented with seizure and weakness of the left half of the body for three months.

Identification of novel pathogenic variants of Calpain-3 gene in limb girdle muscular dystrophy R1.

Background: Limb Girdle Muscular Dystrophy R1 (LGMDR1) is an autosomal recessive neuromuscular disease caused by mutations in the calpain-3 (CAPN3) gene. As clinical and pathological features may overlap with other types of LGMD, therefore definite molecular diagnosis is required to understand the progression of this debilitating disease. This study aims to identify novel variants of CAPN3 gene in LGMDR1 patients.

Primary Rosai-Dorfman disease of the central nervous system: A clinical, histological, and molecular appraisal.

Rosai-Dorfman disease (RDD) is characterized by clonal proliferation of S-100 positive histiocytes and variable emperipolesis. It commonly affects cervical lymph nodes. Central nervous system (CNS) involvement is extremely rare.