Genome-wide association study of neuropathic pain phenotypes implicates loci involved in neural cell adhesion, channels, collagen matrix formation, and immune regulation.

Neuropathic pain is a common and debilitating symptom with limited treatment options. Genetic studies, which can provide vital evidence for drug development, have identified only 3 genome-wide significant signals for neuropathic pain traits. To address this, we performed the largest genome-wide association study (GWAS) to date of all-cause neuropathic pain and neuropathic pain subtypes.

A-to-I edited SNHG3 promotes non-small cell lung cancer metastasis by promoting fatty acid oxidation and resisting ferroptosis.

Adenosine-to-inosine (A-to-I) RNA editing is a critical post-transcriptional modification that enhances tumor genome diversity and contributes to cancer progression. In non-small cell lung cancer (NSCLC), while specific A-to-I editing events have been identified, their functional mechanisms and clinical relevance remain poorly understood. Here, through whole-transcriptome analysis of NSCLC specimens, we discovered a hyper-editing event at position c.

Serum Creatine Phosphokinase Level as a Prognostic Marker for Organophosphorus Poisoning and Its Correlation With Peradeniya Organophosphorus Poisoning Scale.

Introduction: Organophosphorus (OP) compounds are widely used as insecticides in agriculture. The Peradeniya Organophosphorus Poisoning (POP) scale is a simple and effective system for determining the severity of OP poisoning. An increase in serum creatinine phosphokinase (CPK) levels in OP poisoning can be due to persistent oxidative cellular damage to muscle membranes.

Comparing Pediatric Dermatology Research Funded by the US National Institutes of Health (NIH) With the US Skin Disease Burden in Patients Under 20 Years Old.

Background: Disease burden, measured by disability-adjusted life years (DALYs), is a helpful metric to guide research funding priorities. Pediatric dermatologic conditions significantly contribute to DALYs, yet it is unclear whether NIH funding reflects this burden.

Objectives: To compare NIH-funded dermatology research with the most burdensome skin diseases in the United States for patients under 20 years old, as measured by DALYs, and to identify mismatches between funding and disease burden.