Demethoxycurcumin induces apoptosis and reduces cell migration by affecting AKT/mTOR-dependent autophagy in human glioma U87MG and T98G cell lines.

Background: Standard treatment for glioblastoma includes chemotherapy, alkylating agents such as temozolomide (TMZ); however, MGMT resistance leads to recurrence. Demethoxycurcumin (DMC) has been reported to inhibit cancer cell growth, induce apoptosis, and prevent metastasis in different cancer models. We investigated the DMC-induced apoptosis and autophagy via inhibition of the AKT/mTOR pathway in human glioma U87MG and T98G cell lines.

Biomimetic nanocarriers for the therapy and management of intestinal inflammations.

Intestinal inflammation particularly inflammatory bowel disease poses significant clinical challenges due to its chronic nature, limited treatment efficacy and adverse effects of conventional therapies like corticosteroids and biologics. Biomimetic nanocarriers have emerged as a transformative strategy to overcome these limitations by leveraging natural cell membranes for targeted drug delivery. This review critically examines the application of biomimetic nanocarriers as precision therapeutics for intestinal inflammation.

Post-traumatic Distal Femoral Salter-Harris Type II Fracture Unmasking an Incidental Osteochondroma as a Possible Stress Riser: A Case Report With Surgical Management.

Osteochondromas are the most common benign bone tumors and are frequently discovered incidentally in the metaphyseal regions of long bones during growth. While typically asymptomatic, they may occasionally lead to complications such as neurovascular impingement, mechanical irritation, or pathological fractures. Salter-Harris type II fractures represent the most frequent physeal injuries in pediatric populations, particularly in rapidly growing regions like the distal femur.

Solid-State Supercapacitors with Enhanced Performance Using Al-Doped Li Ion Perovskite Electrolyte Integrated with Carbon Aerogel Electrode.

We report the performance of solid-state ceramic supercapacitors (SSCs) based on a novel composite electrolyte comprising aluminum-doped lithium lanthanum titanate perovskite, LiLaTiAlO (Al-doped LLTO), and the ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIM BF). Rietveld refinement of X-ray diffraction data confirms the preservation of the tetragonal perovskite phase after Al substitution, indicating structural stability of the host lattice. X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy further corroborate the successful incorporation of Al without forming secondary phases.

MicroRNAs and synaptic dysfunction in Parkinson's disease.

Parkinson's disease (PD) is a debilitating neurodegenerative condition. Synaptic dysfunctions are associated with the onset and progressive neurodegeneration exhibited in PD. Healthy, active synapses are a prerequisite for non-pathological neurotransmission.