A T-cell-based metric of immune age predicts outcomes in older patients with myeloma receiving daratumumab-based therapy.

Immunotherapy has transformed the treatment landscape of multiple myeloma (MM), a hematological cancer predominantly affecting older individuals. Yet, whether immune aging, shaped by intrinsic aging processes, genetics and external factors, impacts treatment efficacy remains unclear. To address this, we investigated the influence of age on the immune system in MM patients and explored whether immune aging associates with clinical outcomes in older patients.

Childbirth Experiences in the United Kingdom Compared to the Netherlands: A Cross-Sectional Survey Study.

Introduction: This study was performed to compare childbirth experiences in the United Kingdom (UK) and the Netherlands (NL) and identify determinants of positive childbirth experiences in both countries.

Methods: Women who gave birth in the UK (n = 1303) or the NL (n = 900) between January 2017 and December 2020 who filled in the cross-sectional Babies Born Better survey were included in this study. Fully adjusted logistic regression models were used to assess differences in the odds of a positive childbirth experience between the two countries.

Birth Outcomes After Sexual Violence and the Role of Disclosure to the Maternity Care Provider.

Background: Sexual violence (SV) history is associated with various birth outcomes. Yet, the underlying mechanisms of these associations have not been sufficiently explained. Disclosure of SV history to a maternity care provider may play an important role in maternity care providers' choice for birth interventions and in women's birth experience.