Isolated oral CD30+/CD4+ CAR+ T-cell lymphoma in long-term remission after radiotherapy.

A Chimeric Antigen Receptor (CAR) positive CD30+/CD4+ T-cell lymphoma (TCL) manifested as a single oral ulceration 22 months after treatment with tisagenlecleucel (tisa-cel), an anti-CD19 CAR T-cell based therapy. TCL showed lentiviral integration in ANKHD1-EIF4EBP3, loss of function of TET2, and NTRK1 copy number gain, suggesting that genetic alterations unrelated to insertional mutagenesis contributed to lymphomagenesis. The patient remains in remission two years after radiotherapy.

Unstable carotid plaque resembling carotid web: a diagnostic challenge in acute ischaemic stroke with rapid response to tenecteplase.

We present the case of an African American man in his mid-to-late 40s with no prior vascular risk factors who developed an acute ischaemic stroke. Imaging revealed an unstable carotid plaque with an associated floating thrombus, resembling a carotid web. The patient demonstrated near-complete neurological recovery within 30 min following intravenous tenecteplase administration.

Blood Flow Restriction during Rest Periods of High-intensity Interval Training Enhances Endurance Performance: A Randomized Placebo-Controlled Study.

Purpose: This study investigated the effects of incorporating blood flow restriction (BFR) during rest periods between sets of high-intensity interval training (HIIT) on aerobic, sprint, and muscular performance in recreationally active participants.

Methods: Forty healthy males (28.7 ± 6.

Dish swap across a weekly menu can deliver health and sustainability gains.

A weekly canteen menu comprising 15 dishes (3 dishes × 5 days) has 1.4 million unique configurations. Here food choice was monitored over four weeks ( ~ 5,000 meals) in a UK university residence.

Charting the use of mini-clinical evaluation exercise (mini-CEX) in nursing and dental education: a bibliometric analysis from the Web of Science database.

Background: Workplace-based assessments, such as the mini-clinical evaluation exercise (mini-CEX), are increasingly used to evaluate clinical competence in authentic healthcare settings. This study aimed to map and evaluate the global research landscape of mini-CEX in nursing and dental education through bibliometric analysis.

Methods: A literature search was conducted in the Web of Science Core Collection on July 1, 2025, using the terms "mini-CEX," "mini clinical evaluation exercise," "nursing," "nurse," "dental," and "dentistry.