Efficacy and safety of nitazoxanide and escitalopram as adjuvant therapies in patients with rheumatoid arthritis: a randomized controlled study.

Objective: This research aimed at evaluating the effectiveness and safety of nitazoxanide and escitalopram as adjuvant therapies in patients with rheumatoid arthritis (RA).

Methods: In this randomized controlled parallel study, 90 patients with active RA were randomized into three groups; group 1 (control group; n = 30) which received traditional therapy, group 2 (Nitazoxanide group; n = 30) which received traditional therapy plus 1 gm/day oral nitazoxanide, and group 3 (Escitalopram group; n = 30) which received traditional therapy plus 10 mg/day oral escitalopram for three months. At baseline and 3 months after treatment, clinical and functional assessments were done through the 28-joint count disease activity score using C-reactive protein (DAS28-CRP), the health assessment questionnaire-disability index (HAQ-DI), and the patient's global assessment (PGA).

Cardiac nuclear imaging workforce: Trends from Medicare Part B (2013-2022).

Background: Cardiac positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are widely used for the assessment of coronary artery disease. While SPECT remains more available, workforce shortages and training demands contribute to geographic disparities in PET availability, impacting patient access to advanced imaging. Therefore, we assessed trends in the U.

Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities.

Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production. Thus, exploring of a fungal isolate with a reliable robustness for Taxol biosynthesis is the objective of this study. Although, Encephalartos bubalinus has diverse ethnopharmaceutical properties, however, the identity of its endophytic fungi remains poorly explored.

First case of primary CNS lymphoma in a patient with severe combined immunodeficiency carrying a novel ZAP70 mutation: a case report.

Introduction: Zeta-chain-associated protein kinase 70 () is a tyrosine kinase that plays a crucial role in T-cell activation via the T-cell receptor/CD3 complex and contributes to B-cell signaling. variants can cause a range of immunodeficiencies with variable clinical presentations, including infections and malignancies.

Case Presentation: A 4-year-old boy presented with chronic cough, dyspnea, recurrent chest infections, and failure to thrive.

Cicer arietinum extract as antitumor and protective agent against Ehrlich Solid Carcinoma-bearing mice.

Background: Cancer remains a significant global health challenge. Several plant-derived compounds have garnered the attention of cancer research for their anticancer effects. Chickpea (Cicer arietinum) is one of the top nutritious legumes with promising chemoprotective effects.