Tailored transethosomal systems for tadalafil transdermal delivery: Impact of Phosal and edge activators on skin permeation and cellular uptake.

Tadalafil (TDLF), a Biopharmaceutics Classification System (BCS) Class II drug, exhibits poor aqueous solubility and extensive first-pass metabolism, which limits its therapeutic efficacy. We developed Phosal-based transethosomes (TrEthOs) to overcome these challenges, thereby enhancing transdermal delivery. A Box-Behnken design was employed to optimize the formulation by evaluating the effects of Phosal type, polyethylene glycol (PEG) 400 concentration, and cholesterol content.

Prevalence of methicillin-resistant and associated factors from surgical ward inpatients at Shaafi Hospital, Mogadishu, Somalia.

Objectives: Methicillin-resistant (MRSA) causes severe infections with high mortality rates and health care costs. This study aimed to evaluate the prevalence of MRSA and its associated factors among patients with wound infections at Shaafi Hospital in Mogadishu, Somalia.

Methods: Wound swabs were collected from 418 patients with surgical wounds and cultured on Mannitol salt agar.

ArEEG: an Open-Access Arabic Inner Speech EEG Dataset.

Recent advancements in Brain-Computer Interface (BCI) technology are shifting towards inner speech over motor imagery due to its intuitive nature and broader command spectrum, enhancing interaction with electronic devices. However, the reliance on a large number of electrodes in available datasets complicates the development of cost-effective BCIs. Additionally, the lack of publicly available datasets hinder the development of this technology.