Economic burden and cost-effectiveness of treatments for open tibia fractures in Malawi: Economic analysis of a multicentre prospective cohort study.

Background: Open tibia fractures result in substantial lifelong disability for patients, and are expensive to treat. As the injury typically affects young working men, the societal costs from open tibia fractures are likely to also be high in low income countries, but remain largely unknown. We therefore investigated the overall societal costs and cost-effectiveness of different orthopaedic treatments at one year following an open tibia fracture in Malawi.

Canadian perinatal opioid project: a protocol for a national health data system.

Introduction: Opioids are widely used during pregnancy and can lead to health complications for pregnant people, parents and their children. Yet, little is known about the long- and short-term effects of perinatal opioid exposures on health outcomes in Canada. Evidence is needed to inform optimal support for maternal and child health following perinatal opioid exposures.

Combining four patient-reported outcome measurement instruments to develop a common metric computerized adaptive test to measure outcome after total knee arthroplasty.

Aims: To map the Oxford Knee Score (OKS), OKS Activity & Participation Questionnaire, Forgotten Joint Score (FJS), and High Activity Arthroplasty Score to a common scale using principles of modern test theory. Using the common scale, we then aimed to build a computerized adaptive test (CAT) to reduce item burden.

Methods: Participants undergoing total knee arthroplasty provided preoperative and postoperative (six and 12 months) paired responses for four patient-reported outcome measure (PROM) instruments, with the OKS being the common linking instrument.

Trends in Term-Equivalent Age Brain Volumes in Infants Born Across the Gestational Age Spectrum.

Purpose: Our understanding of the influence of preterm birth and related perinatal exposures on early brain development is limited, hampering personalized optimization of neuroprotective strategies. This study assesses the effect of gestational age (GA) at birth on brain volumes at term-equivalent age (TEA) in infants without overt brain injury born across the GA spectrum.

Methods: A cohort of infants born across the GA spectrum (25-40 weeks' gestation) underwent 3T brain MRI around TEA (40-46 weeks postmenstrual age).