Clinical outcomes of neuroendocrine carcinoma of the cervix: Retrospective review from a large academic cancer centre.

Objective: Neuroendocrine cervical carcinomas are a rare but aggressive malignancy associated with a poor prognosis and there is limited evidence to guide clinical decision-making. Our objective was to evaluate the patterns of practice and clinical outcomes of patients diagnosed with neuroendocrine cervical carcinoma.

Methods: This was a retrospective chart review of patients diagnosed with neuroendocrine cervical carcinoma between 2007 and 2023.

Can a Matched Case-Control Methodology Efficiently Estimate Functional Relationships between Knee Implant Alignment and Revision Risk? A Simulation-Based Analysis.

Background: Conventional randomized controlled trials are generally too underpowered to yield meaningful insights into the functional dependence of revision risk on surgeon-controlled implant alignment. However, matched case-control studies focused on patients undergoing revision surgery could produce such insights. We therefore asked, can we determine, through simulation, whether such matched case-control study designs could potentially produce sufficiently accurate estimates of the functional relationships between surgeon-controlled variables and aseptic revision risk to inform surgical alignment targets for total knee arthroplasty?

Methods: We evaluated the potential for a matched case-control methodology to achieve this goal using a simulation approach in which we characterized individual patients' risk of revision by Implant Life Factor (ILF) functions that reflected the effects of both surgeon-controlled and patient-specific factors.

Healthcare providers' perspectives and experiences caring for individuals with lower limb absence during the perinatal period: a qualitative study.

Purpose: This study explored healthcare providers' (HCPs') experiences providing care for individuals with lower limb amputation (LLA) during the perinatal period, the perceived impact of pregnancy on individuals with LLA, and strategies to improve perinatal support for individuals with LLA.

Methods: This is a qualitative descriptive study. Semi-structured interviews were conducted with HCPs with experience caring for individuals with LLA during the perinatal period.

Effect of High Zn Concentration on the Structural, Electrical, and Magnetic Properties of Zn-Doped Yttrium Iron Garnet Nanoparticles.

Current-induced magnetoelectric (ME) effect offers the potential for broadband, low-power tunable microwave devices. While yttrium iron garnet (YIG) is the most used ferrite due to its superior magnetic properties, its high-quality dielectric properties hinder its potential tuning with an electric current. To increase YIG's conductivity, we investigated Zn-doped YIG nanoparticles and nanocomposites (YFe Fe Zn O) synthesized using the sol-gel method within a broad concentration range of dopants (0 < < 1.

Oncologic and fertility outcomes of progestin therapy for atypical hyperplasia and grade 1 cancer of the endometrium: Results of a specialized oncofertility program.

Objective: This study describes the oncological and fertility outcomes of patients with atypical hyperplasia (AH) or low-grade endometrial cancer (EC) desiring fertility preservation, enrolled in a specialized oncofertility program.

Methods: Patients referred between 2019 and 2024 were reviewed. This novel program provides integrated oncologic and reproductive endocrinology and infertility (REI) care, following standardized treatment pathways.