Unveiling therapeutic potential: In Silico discovery of prognostic markers and potential inhibitors for TGFßR1 in pancreatic cancer.

Pancreatic cancer remains one of the lethal malignancies. Characterised by low survival rates, resistance to conventional chemotherapy and a lack of early detection markers. Differentially expressed genes AHNAK2, TSC2, LAMC2, C3orf52 and IGFBP3 were identified as significant prognostic markers based on their expression pattern and poor patient survival.

Testosterone Suppresses IL-17 Expression by Targeting RORγt Functions.

Th17 cells play a crucial role in autoimmune disease pathogenesis. However, the mechanisms behind the sex differences in immune responses, particularly women's higher susceptibility to autoimmune diseases, remain unclear. This study investigated the role of testosterone in modulating the IL-17 response.

Lumazine Synthase Nanoparticles as a Versatile Platform for Multivalent Antigen Presentation and Cross-Protective Coronavirus Vaccines.

Lumazine synthase (LS), a bacterial protein that self-assembles into 60-mer icosahedral virus-like nanoparticles, has emerged as a promising platform for nanoparticle-based drug delivery and vaccine design. However, detailed biophysical characterization of the LS nanoparticle vaccine has not been well-studied. In this study, we generated LS nanoparticles fused with domain B of protein A (pA-LS), enabling their binding to the hFc-tagged S1 domain of the SARS-CoV-2 spike protein harboring two critical mutations (E484K and D614G) associated with increased infectivity and antibody escape.