A Bird's-Eye View of the Wings Apart-Like Protein in Cell Biology and Implications for Disease and Therapeutics.

Wings apart-like protein (WAPL) has emerged as a key player in maintaining genome integrity through its regulation of cohesin dynamics, which govern chromatin architecture and gene expression. WAPL mainly acts as a cohesin release factor and ensures proper chromosomal segregation during mitosis by promoting sister chromatid resolution. Owing to its prominent role in cell biology, WAPL dysregulation can cause genomic instability and disrupt chromosomal cohesion, leading to diseases such as cancer.

Targeting Nrf2 in acute myeloid leukemia: an updated review on its role in chemoresistance and emerging therapeutic strategies.

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by the clonal expansion of primitive hematopoietic stem cells. Despite therapeutic advances, including chemotherapy, hypomethylating agents, and FLT3 inhibitors, resistance and relapse remain major clinical challenges. One of the contributors to chemoresistance in AML is the nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates redox homeostasis and promotes cell survival under oxidative stress.

Interventricular septal hematoma following cone repair for Ebstein's anomaly.

Unlabelled: Interventricular septal hematoma (IVSH) is a rare complication following pediatric heart surgery involving interventricular septum (IVS). We present the case of an adult who developed IVSH after cone repair for Ebstein's anomaly and the management challenges involved.

Supplementary Information: The online version contains supplementary material available at 10.

Clinical profile of restrictive cardiomyopathy in children at a South Indian tertiary care cardiac center: A retrospective three decade experience.

Background: Research on pediatric restrictive cardiomyopathy (RCM), especially from the developing world, is limited. The study aimed to describe the clinical features and outcomes of childhood RCM and the predictors of outcome.

Methods: The study included all children with RCM who were < 18 years old.

Phosphoproteomic insights into GFPT2-Associated cellular phospho-signaling networks.

The GFPT2 protein, also known as glutamine-fructose-6-phosphate aminotransferase 2, regulates glucose flux through the hexosamine biosynthesis pathway (HBP). It is primarily expressed in the spinal cord and central nervous system and is notably abundant in various cancers while being dysregulated in diabetes. Despite its significant role in critical diseases, the phospho-regulatory mechanisms governing GFPT2 function remain largely unexplored.